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Importance of Genetic Testing in the Diagnosis of Transthyretin Cardiac Amyloidosis

To the Editor: Systemic amyloidosis results from extracellular deposition of fibrillar material derived from aggregation of precursor proteins into insoluble beta-pleated sheets. The most frequently recognized types are due to prolonged inflammation, deposition of immunoglobulin light chains, and accumulation of transthyretin, a tetrameric protein synthesized in the liver. Transthyretin amyloidosis can occur owing to wild-type […]

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Density plots comparing high-density lipoprotein cholesterol (HDL-C) at baseline in Systolic Blood Pressure Intervention Trial (SPRINT) participants who developed hyponatremia (red) during the study and patients who did not develop hyponatremia (blue). Baseline HDL-C was significantly more elevated in participants who later developed hyponatremia, for both males and females (P <.0001 in both sexes; Wilcoxon test).

Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients

  Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. Our objective in this study was to identify risk […]

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Historical figures in hypertrophic cardiomyopathy. Left: Mr. Claude Brady, the first patient identified clinically with hypertrophic cardiomyopathy at age 22 years, is now 80 years of age. Right: Dr. Eugene Braunwald, who diagnosed Mr. Brady and went on to develop the first clinical profile of this disease in the early 1960s.

Achieving Extended Longevity and Quality of Life for Senior Patients With Hypertrophic Cardiomyopathy

To read this article in its entirety please visit our website. – This article originally appeared in the November 2017 issue of The American Journal of Medicine.

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Demographics and Epidemiology of Sudden Deaths in Young Athletes

  Sudden deaths in young competitive athletes are tragic events, with high public visibility. The importance of race and gender with respect to sport and the diagnosis and causes of sudden death in athletes has generated substantial interest. Methods The US National Registry of Sudden Death in Athletes, 1980-2011, was accessed to define the epidemiology […]

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Demographics and Epidemiology of Sudden Deaths in Young Competitive Athletes (video)

  Sudden deaths in young, seemingly healthy competitive athletes are tragic events, often with wide media coverage and high public visibility. There is substantial interest in establishing the cause of these deaths and the roles that race and gender may play. In a new study published in The American Journal of Medicine, investigators report that […]

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(A) The patient had bossing and macroglossia. (B) Swelling of the soft tissue, along with growth of the bone, cartilage, and muscle, produced enlargement of the hands. (C) The patient's shoe, size 19, is compared with a size 11 shoe.

Power Failure: Acromegalic Cardiomyopathy

Presentation During his college years, the patient, at 6 ft, 8 in and 280 lb, aroused the attention of professional basketball scouts. But exertional fatigue and shortness of breath truncated his athletic aspirations. These symptoms continued in the ensuing years, necessitating approximately 15 hospitalizations at outside institutions for progressive dyspnea. No discernible etiology was established […]

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