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Importance of Genetic Testing in the Diagnosis of Transthyretin Cardiac Amyloidosis

To the Editor: Systemic amyloidosis results from extracellular deposition of fibrillar material derived from aggregation of precursor proteins into insoluble beta-pleated sheets. The most frequently recognized types are due to prolonged inflammation, deposition of immunoglobulin light chains, and accumulation of transthyretin, a tetrameric protein synthesized in the liver. Transthyretin amyloidosis can occur owing to wild-type […]

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Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients

  Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. Our objective in this study was to identify risk […]

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Achieving Extended Longevity and Quality of Life for Senior Patients With Hypertrophic Cardiomyopathy

To read this article in its entirety please visit our website. – This article originally appeared in the November 2017 issue of The American Journal of Medicine.

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Demographics and Epidemiology of Sudden Deaths in Young Athletes

  Sudden deaths in young competitive athletes are tragic events, with high public visibility. The importance of race and gender with respect to sport and the diagnosis and causes of sudden death in athletes has generated substantial interest. Methods The US National Registry of Sudden Death in Athletes, 1980-2011, was accessed to define the epidemiology […]

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Demographics and Epidemiology of Sudden Deaths in Young Competitive Athletes (video)

  Sudden deaths in young, seemingly healthy competitive athletes are tragic events, often with wide media coverage and high public visibility. There is substantial interest in establishing the cause of these deaths and the roles that race and gender may play. In a new study published in The American Journal of Medicine, investigators report that […]

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