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Chest Pain in a 39-Year-Old Man: What Could Be the Underlying Cause?

  A 39-year-old man with unremarkable past medical history, but with a positive family history for coronary artery disease, was admitted to the hospital because of persistent arterial hypertension and sudden-onset chest pain in the mid-substernal region with neck radiation. Assessment Results from physical examination were unremarkable. The 12-lead electrocardiogram and the cardiac biomarkers were […]

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The Sweatshirt Sign: Coronary Artery Disease

  In one memorable case, the patient’s attire told physicians more about his health than the initial interview and physical examination. A 65-year-old veteran with a history of dyslipidemia, hypothyroidism, and post-traumatic stress disorder presented for a routine primary care visit and had no symptoms. He specifically denied having any chest pain. Assessment When asked […]

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nurse showing an elderly woman something on a tablet in office

Coronary Artery Disease Among Postmenopausal Women

  Epidemiological studies have shown a higher risk of cardiovascular mortality associated with early menopause, but the relation between menopausal age and extent of coronary artery disease after menopause is unknown. We assessed the relation between menopausal age and extent of coronary disease in postmenopausal women with an acute coronary syndrome. Methods A prospective study […]

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Triple vs Dual Antithrombotic Therapy in Patients with AF & CAD

Background The role of triple antithrombotic therapy vs dual antithrombotic therapy in patients with both atrial fibrillation and coronary artery disease remains unclear. This study explores the differences in treatment practices and outcomes between triple antithrombotic therapy and dual antithrombotic therapy in patients with atrial fibrillation and coronary artery disease. Methods Using the Outcomes Registry […]

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Warfarin and Vascular Calcification

  The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that […]

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