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An Approach to Myopathy for the Primary Care Clinician

Patients with muscle weakness are frequently encountered in the primary care clinic; however, the identification of an underlying disorder of muscle can pose a significant challenge. The aim of this review article is to provide a clinical and diagnostic framework to aid the primary care clinician in the detection and evaluation of suspected myopathies. Introduction […]

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Nonobstructive Hypertrophic Cardiomyopathy Out of the Shadows (video)

Hypertrophic cardiomyopathy was first recognized as a disease of obstruction to left ventricular outflow, hence, its early names and acronyms such as idiopathic hypertrophic subaortic obstruction. The nonobstructive subset of patients, incapable of developing mechanical impedance to left ventricular outflow at rest or with physiologic exercise, was initially recognized by the Braunwald group at the […]

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Statin-induced Myopathy: Hypothesis About Randomized Evidence and Clinical Impressions

Myopathy refers to any muscle disease, myalgia to muscle aches or weakness without creatine kinase elevation, and myositis includes increased creatine kinase. Rhabdomyolysis includes marked creatine kinase elevations usually with brown urine and urinary myoglobin.(1) Statins confer statistically significant and clinically important reductions in myocardial infarction, stroke, and cardiovascular death.2 The class is well tolerated, […]

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