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Painful Violaceous Purpura on a 44-Year-Old Woman

Returning to the fundamentals of our medical training, eliciting a full social history, including the use of illicit drugs, can be the key to making a correct diagnosis. This point is illustrated in the following case. A 44-year-old woman with a past medical history notable for asthma and heroin abuse, presented to the Emergency Department […]

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Systemic Inflammation Gone Awry: PASH Syndrome and Temporomandibular Joint Ankylosis

The development of new symptoms in a patient with hidradenitis suppurativa led to the recognition of a systemic autoinflammatory condition. A long battle with hidradenitis suppurativa and acne became even more difficult for a 24-year-old man who developed increasing pain and malodorous drainage from the chronic subcutaneous nodules on his axillae, groin, and buttocks, as […]

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Rash and Fever: Clues to an Elusive Hematologic Malignancy

In a previously healthy older adult, a generalized rash gave way to an elusive diagnosis. Six weeks before the present hospitalization and after a period of sun exposure, this 65-year-old woman developed a pruritic rash on her arms, legs, and trunk that spared her face, palms, and soles. Shortly thereafter, the rash was followed by […]

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Psoriasis

Treatment of Psoriasis with Mesenchymal Stem Cells

  Psoriasis is an incurable immune-mediated disease, which affects approximately 2% of the world’s population. Current treatments, including newly emerged biologic agents, have some limitations.1 Here, we report 2 cases of psoriasis vulgaris treated by umbilical cord-derived mesenchymal stem cells (UC-MSCs). In these 2 cases, both of the patients remained relapse free for 4 or 5 […]

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Pyoderma Gangrenosum Associated with Acute Respiratory Distress Syndrome

To the Editor: Pyoderma gangrenosum is a rare neutrophilic dermatologic disorder that presents as painful necrotic ulcers. It can also involve the lungs and the kidneys. The etiology remains unclear. However, it has recently been reported that cytokines may play a key role in pyoderma gangrenosum’s pathogenesis. Similarly, acute respiratory distress syndrome is characterized as lethal […]

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