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Erythematous plaques with thick, micaceous scale on the extensor lower leg of a man with plaque psoriasis.

Psoriasis and Psoriatic Spectrum Disease: A Primer for the Primary Care Physician

Psoriasis is a chronic, immune-mediated disorder with cutaneous, articular, and systemic manifestations that are associated with significant morbidity.1 The burden of disease is directly related to its prevalence, which ranges from 0.5%-11.4% in adults and 0%-1.4% in children worldwide.2 In the United States alone, approximately 7.4 million individuals have psoriasis,3 and both the incidence and prevalence of psoriasis […]

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Psoriasis

Treatment of Psoriasis with Mesenchymal Stem Cells

  Psoriasis is an incurable immune-mediated disease, which affects approximately 2% of the world’s population. Current treatments, including newly emerged biologic agents, have some limitations.1 Here, we report 2 cases of psoriasis vulgaris treated by umbilical cord-derived mesenchymal stem cells (UC-MSCs). In these 2 cases, both of the patients remained relapse free for 4 or 5 […]

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48-year-old man with severe psoriasis and calcified coronary lesions on CCTA (left); 57-year-old man with severe lifelong atopic dermatitis and mixed coronary plaque in the LAD on CCTA (middle), and no plaques in the RCA (right). CCTA = cardiac computed tomography angiography; LAD = left anterior descending artery; RCA = right coronary artery.

Increased Prevalence of Coronary Artery Disease in Severe Psoriasis and Severe Atopic Dermatitis

Atopic dermatitis  and psoriasis, a systemic inflammatory disease thought to be linked to a range of comorbidities, are associated with an increased prevalence of coronary artery disease. Background Psoriasis and atopic dermatitis (AD) are immuno-inflammatory diseases that can result in lifelong systemic inflammation. Unlike AD, psoriasis has been associated with cardiovascular disease. The aim of […]

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Attributable Risk Estimate of Severe Psoriasis on Major Cardiovascular Events

Patients with severe psoriasis have an additional 6.2% absolute risk of major adverse cardiac events compared to the general population. This finding could have important therapeutic implications for cardiovascular risk stratification and prevention in patients with severe psoriasis. Abstract Background Recent studies suggest that psoriasis, particularly if severe, may be a risk factor for major […]

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