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Independent of Cirrhosis, Hepatocellular Carcinoma Risk Is Increased with Diabetes and Metabolic Syndrome

Hepatocellular carcinoma is the most common primary liver malignancy, commonly a sequelae of hepatitis C infection, but can complicate cirrhosis of any cause. Whether metabolic syndrome and its components, type II diabetes, hypertension, and hyperlipidemia increase the risk of hepatocellular carcinoma independent of cirrhosis is unknown. Methods A retrospective cohort study was conducted using the MarketScan insurance […]

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woman staring at the alarm clock in bed

Short Sleep Duration & Impaired Glycemic Control (video)

Is insomnia linked to poor glycemic control? In this study, people who habitually slept less than seven hours per night had elevated glucose levels, as measured by morning oral glucose tolerance test. In this video, American Journal of Medicine Editor-in-Chief Dr. Joseph Alpert explains the clinical implications of the findings. Read the Research: Habitual and Recent […]

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Joseph S. Alpert

Statins and Diabetes: Wider Utilization Is Needed in Treatment and Prevention

  In this issue of The American Journal of Medicine, Hennekens et al1 address many cogent methodologic issues concerning whether there is a valid statistical association between statins and the development of diabetes. While they conclude that the current totality of evidence is insufficient to confirm a valid association, if such an association were present, the most plausible […]

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nurse holding hand of elderly woman patient

Dipeptidyl Peptidase-4 Inhibitors, Peripheral Arterial Disease, and Lower Extremity Amputation Risk in Diabetic Patients

Recent studies have elucidated the vascular protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitors. However, to date, no large-scale studies have been carried out to determine the impact of DPP-4 inhibitors on the occurrence of peripheral arterial disease, and lower extremity amputation risk in patients with type 2 diabetes mellitus. Methods We conducted a retrospective registry […]

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Periodontal Pocket Depth, Hyperglycemia, and Progression of Chronic Kidney Disease

No large epidemiological study has been conducted to investigate the interaction and joint effects of periodontal pocket depth and hyperglycemia on progression of chronic kidney disease in patients with periodontal diseases. Methods Periodontal pocket depth was utilized for the grading severity of periodontal disease in 2831 patients from January 2002 to June 2013. Progression of […]

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