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Nutraceuticals: Evidence of Benefit in Clinical Practice?

Nutraceuticals, according to Wikipedia, are food substances or nutritional supplements that have beneficial effects on health. They are not usually considered to be part of a normal diet, such as fruit, vegetable, fish, and meat. Rather, they are additives, usually derived from plants, which are said to be beneficial at preventing or treating illnesses. The term nutraceutical, […]

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Mindfulness Meditation Modulates Pain Through Endogenous Opioids

  Recent evidence supports the beneficial effects of mindfulness meditation on pain. However, the neural mechanisms underlying this effect remain poorly understood. We used an opioid blocker to examine whether mindfulness meditation-induced analgesia involves endogenous opioids. Methods Fifteen healthy experienced mindfulness meditation practitioners participated in a double-blind, randomized, placebo-controlled, crossover study. Participants rated the pain […]

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A Tool to Assess Risk of De Novo Opioid Abuse or Dependence

Readily available demographic, clinical, behavioral, pharmacy, and geographic information can be used to predict the likelihood of opioid abuse or dependence. Determining risk factors for opioid abuse or dependence will help clinicians practice informed prescribing and may help mitigate opioid abuse or dependence. The purpose of this study is to identify variables predicting opioid abuse […]

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Painful Violaceous Purpura on a 44-Year-Old Woman

Returning to the fundamentals of our medical training, eliciting a full social history, including the use of illicit drugs, can be the key to making a correct diagnosis. This point is illustrated in the following case. A 44-year-old woman with a past medical history notable for asthma and heroin abuse, presented to the Emergency Department […]

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Warfarin and Vascular Calcification

  The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that […]

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