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Photograph of the patient's face shows bilateral periorbital ecchymosis (raccoon eye appearance).

Raccoon Eye Appearance: Amyloidosis

To the Editor: An 82-year-old woman presented to our outpatient clinic with a 6-month history of recurrent internal bleeding near the eyes. The patient had a history of type 2 diabetes mellitus, but had no significant medical history including traumatic injuries. Physical examination revealed bilateral periorbital ecchymosis and large tongue (Figure). Serum protein electrophoresis revealed […]

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Large lower limb edemas caused by diffuse hematomas from the legs to the thighs before (A, B) and after vitamin C supplementation (C).

Unexpected Cause of Bleeding

To the Editor: A 46-year-old man was seen by his hepatologist for a follow-up visit after successful treatment of hepatitis C. He reported a general weakness and walking pain for 10 days due to lower limb edema and knee arthralgia. His medical history included an intravenous heroin and cocaine addiction weaned off since 2001 and […]

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The Clinical Course of Venous Thromboembolism May Differ According to Cancer Site

We hypothesized that the clinical course of venous thromboembolism in patients with active cancer may differ according to the specificities of primary tumor site. Aim and Methods We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes during the course of anticoagulation in patients with one […]

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Axial contrast-enhanced CT image shows the left renal vein (arrow) being compressed between the superior mesenteric artery (*) and the abdominal aorta (A).

Blood in Urine: A Hard Nut to Crack

A 34-year-old woman presented with a 2-week history of intermittent painless macroscopic hematuria. She had a similar episode of macroscopic hematuria 5 years ago during her last pregnancy, which resolved spontaneously. Apart from this, she had no significant medical history. She was not taking any regular medications or supplements. On examination, she appeared well. She […]

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measuring belly fat with calipers

Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting

Several studies have demonstrated an association between body mass index (BMI) and warfarin therapeutic dose, but none evaluated the association of BMI with the clinically important outcome of major bleeding in a community setting. To address this evidence gap, we conducted a case–control study to evaluate the association between BMI and major bleeding risk among […]

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Dental Surgery and Antiplatelet Agents: Bleed or Die

In patients taking antiplatelet medications who are undergoing dental surgery, physicians and dentists must weigh the bleeding risks in continuing antiplatelet medications versus the thrombotic risks in interrupting antiplatelet medications. Bleeding complications requiring more than local measures for hemostasis are rare after dental surgery in patients taking antiplatelet medications. Conversely, the risk for thrombotic complications […]

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