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Effectiveness and Safety of Rivaroxaban Versus Warfarin in Frail Patients with Venous Thromboembolism

Frailty predicts poorer outcomes in patients receiving anticoagulation. We assessed the effectiveness and safety of rivaroxaban vs warfarin in frail patients experiencing venous thromboembolism. Methods Using US MarketScan claims data from January 2012-December 2016, we identified frail patients (using the Johns Hopkins Claims-Based Frailty Indicator score) who had ≥1 primary hospitalization/emergency department visit diagnosis codes […]

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Bone Density Testing Is the Best Way to Monitor Osteoporosis Treatment

Bone mineral density assessment by dual-energy X-ray absorptiometry is the most widely available and best validated clinical tool to diagnose osteoporosis, assess fracture risk, and monitor the skeletal effects of medications that reduce fracture risk.1 However, dual-energy X-ray absorptiometry testing remains underused with osteoporosis undertreated. This treatment gap has reached crisis proportions,2 with recent disturbing evidence that […]

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Delayed Transient Cortical Blindness from Hypoxic Ischemic Encephalopathy

To the Editor: An 85-year-old woman with no significant past medical history presented after a mechanical fall complicated by multiple fractures. She received intravenous pain medications with resultant decreased level of consciousness and respiratory distress. Intubation was difficult because of bilateral mandibular fractures, and she consequently experienced 10 minutes of hypoxia before secure airway control […]

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Sudden Hip Pain in a Young Woman

Here we present a case history of a 29-year-old woman who was admitted to the Department of Orthopedics due to severe pain in the left hip occurring after minimal trauma. Surprisingly, radiography demonstrated the presence of a pathological fracture of the left femoral neck. However, this was not the only abnormality visible on the radiograms. […]

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Osteoporosis in the Women’s Health Initiative: Another Treatment Gap?

Osteoporotic fractures are associated with high morbidity, mortality, and cost. Methods We performed a post hoc analysis of the Women’s Health Initiative (WHI) clinical trials data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis or fracture. Information from visits prior to and immediately subsequent […]

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