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Double Fixation: Bilateral Bisphosphonate-Related Hip Fractures

Bisphosphonates have been in use since the 1960s for the treatment of osteoporosis. They reduce bone resorption by inhibiting the action of osteoclast cells and also by inducing osteoclast apoptosis.1, 2 Since 2005, multiple studies have shown an increased prevalence of minimal-trauma subtrochanteric and diaphyseal femoral fractures in patients taking long-term bisphosphonate therapy.2, 3, 4, 5, 6, 7, 8, 9, 10 It is presumed that bisphosphonates […]

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Diuretic Use and Risk of Vertebral Fracture in Women

  Vertebral fracture is the most common type of osteoporotic fracture. While thiazide diuretics, which are commonly prescribed for the treatment of hypertension, decrease calciuria, they may also induce hyponatremia, which has been associated with increased vertebral fracture risk. Loop diuretics increase calciuria, which would reduce bone mineral density and increase vertebral fracture risk, but […]

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Vertebral Fractures: Clinical Importance and Management

  Vertebral fractures are the most common type of osteoporotic fracture and are associated with substantial morbidity and decreased survival. In the United States, annual direct management costs for vertebral fractures are more than $1 billion (United States dollars in 2011). Vertebral fracture, once suspected, can be confirmed by X-rays, computerized tomography, magnetic resonance imaging, or vertebral […]

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