American Journal of Medicine, internal medicine, medicine, health, healthy lifestyles, cancer, heart disease, drugs

Looking for Sarcopenia Biomarkers

Sarcopenia, defined as age-associated loss of skeletal muscle mass and function, has emerged as an important public health issue. It is associated with higher mortality, morbidity, physical disability, and health care cost.1, 2While sarcopenia should be diagnosed with measurements of muscle mass and function, serum biomarkers are needed for screening of sarcopenia in a large population. […]

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doctor talking on cell phone stting at his desk, looking at computer

The New Trend in Medicine

During the 4 decades of my clinical training and practice of medicine, I always felt a sense of ownership and full responsibility in caring for my patients. What I have noticed over the past decade is a gradual transformation in our health care delivery system and in the attitude of our trainees. Hospitals are being governed […]

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Joseph S. Alpert

Statins and Diabetes: Wider Utilization Is Needed in Treatment and Prevention

  In this issue of The American Journal of Medicine, Hennekens et al1 address many cogent methodologic issues concerning whether there is a valid statistical association between statins and the development of diabetes. While they conclude that the current totality of evidence is insufficient to confirm a valid association, if such an association were present, the most plausible […]

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Absence of Oral Anticoagulation and Subsequent Outcomes Among Outpatients with Atrial Fibrillation

Prior studies have shown a treatment gap in oral anticoagulation (OAC) use among patients with atrial fibrillation yet have incompletely characterized factors associated with failure to treat and subsequent outcomes in contemporary practice. Methods Using data collected between June 2010 and August 2011 from 174 ambulatory care sites in the Outcomes Registry for Better Informed […]

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doctor testing for blood pressure

Treatment-Resistant Hypertension and Outcomes Based on Randomized Treatment Group in ALLHAT

  Although hypertension guidelines define treatment-resistant hypertension as blood pressure uncontrolled by ≥3 antihypertensive medications, including a diuretic, it is unknown whether patient prognosis differs when a diuretic is included. Methods Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were randomly assigned to first-step therapy with chlorthalidone, amlodipine, or lisinopril. At a Year […]

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