Tag Archives: Clinical Research

Habitual and Recent Sleep Durations: Graded and Interactive Risk for Impaired Glycemic Control in a Biracial Population

We examined how habitual sleep duration interacts with recent sleep (2 nights) to predict morning oral glucose tolerance test results. We hypothesized that short habitual and recent sleep durations would be additive for poor glucose control. Methods A biracial population of adults (n = 1559) without known diabetes and recruited from the workforce of 2 urban […]

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Absence of Oral Anticoagulation and Subsequent Outcomes Among Outpatients with Atrial Fibrillation

Prior studies have shown a treatment gap in oral anticoagulation (OAC) use among patients with atrial fibrillation yet have incompletely characterized factors associated with failure to treat and subsequent outcomes in contemporary practice. Methods Using data collected between June 2010 and August 2011 from 174 ambulatory care sites in the Outcomes Registry for Better Informed […]

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doctor testing for blood pressure

Treatment-Resistant Hypertension and Outcomes Based on Randomized Treatment Group in ALLHAT

  Although hypertension guidelines define treatment-resistant hypertension as blood pressure uncontrolled by ≥3 antihypertensive medications, including a diuretic, it is unknown whether patient prognosis differs when a diuretic is included. Methods Participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) were randomly assigned to first-step therapy with chlorthalidone, amlodipine, or lisinopril. At a Year […]

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nurse pushes gurney down hospital hallway

Trends in Prolonged Hospitalizations in the United States from 2001 to 2012

Health policy debate commonly focuses on frequently hospitalized patients, but less research has examined trends in long-stay patients, despite their high cost, effect on availability of hospital beds, and physical and financial implications for patients and hospitals. Methods Using the National Inpatient Sample, a nationally representative sample of acute care hospitalizations in the US, we […]

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Smoking Cessation: The Urgent Need for Increased Utilization of Varenicline

In the US, cigarette smoking causes 480,000 premature deaths annually, due mainly to a twofold increased risk of cardiovascular disease and a 20-fold increased risk of lung cancer.1 Public health efforts and effective cessation treatments–including behavioral counseling and medications–have decreased US rates to approximately 14%; they are markedly increasing in most developing countries.2 Smoking and the emerging […]

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