Tag Archives: Drugs

Antidepressants and Hyponatremia

It is well known that antidepressants can cause hyponatremia, particularly in elderly patients. This complication can be serious, with delirium, seizure, or even death. In the classic study by Fabian et al,1 paroxetine, a selective serotonin reuptake inhibitors (SSRI), was found to induce hyponatremia in 12% of elderly patients within a mean duration of 9 days. […]

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Mobile Health Technology for Atrial Fibrillation Management Integrating Decision Support, Education, and Patient Involvement

  Mobile Health technology for the management of patients with atrial fibrillation is unknown. Methods The simple mobile AF (mAF) App was designed to incorporate clinical decision-support tools (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes Mellitus, Prior Stroke or TIA, Vascular disease, Age 65–74 years, Sex category], HAS-BLED [Hypertension, Abnormal renal/liver function, Stroke, […]

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Choosing Wisely? Measuring the Burden of Medications in Older Adults (video)

The burden of medications near the end of life has recently come under scrutiny, because several studies suggested that people with life-limiting illness receive potentially futile treatments. Methods We identified 511,843 older adults (>65 years) who died in Sweden between 2007 and 2013 and reconstructed their drug prescription history for each of the last 12 […]

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Leptomeningeal Infiltration, the Hallmark of Neurosarcoidosis

A 22-year-old human immunodefiency virus–negative man was admitted to the intensive care unit for generalized seizures. The patient’s family reported a 1-month history of asthenia and intermittent confusion. Clinical examination revealed isolated inappropriateness of behavior related to a frontal lobe syndrome, without any neck stiffness or neurologic deficit. The patient’s temperature was 37°C. Results from […]

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Why California’s Proposition 61 Was a Bad Idea

New approaches to control state pharmaceutical costs are needed.1 This issue is particularly critical in California, the state with the largest pharmaceutical expenditures in the country.1 A controversial California ballot initiative aimed at reining in prescription drug expenditures was defeated on November 8, 2016 by a 54% to 46% margin.2The California Drug Price Relief Act, also known […]

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