Tag Archives: editorial
doctor holds tablet and talks to patient

Association Between High-Density Lipoprotein Cholesterol and Hyponatremia

In this issue of The American Journal of Medicine Israel and Grossman1 report an interesting observation based on their analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) and the National Health and Nutrition Examination Survey (NHANES) datasets. They used gradient boosting machines to build predictive models for hyponatremia based on SPRINT participant high-density lipoprotein cholesterol (HDL-C) levels, […]

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Dr. Joseph S. Alpert

Stem Cell Therapy: The Phoenix in Clinical Medicine?

The Phoenix is a mythical bird with brightly colored plumage known in ancient Greek for the legend of its rebirth. After a long life, the Phoenix dies in a fire of its own making and then rises again reborn from the ashes. This myth parallels current feverish beliefs concerning the ability of stem cell therapy […]

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Joseph S. Alpert, MD

Polypharmacy in Elderly Patients: The March Goes On and On

Polypharmacy is a major public health problem in the United States and abroad. Although there is no standard definition of polypharmacy, I see and recognize it every day in the outpatient and inpatient environment. A typical example that I saw yesterday was an 84-year-old man admitted to our internal medicine service for worsening heart failure. […]

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Osteopathic Manipulation in Treatment of Musculoskeletal Chest Pain

Throughout most of my 29 years of practicing clinical cardiology, I was never really satisfied with treatments I employed in the treatment of musculoskeletal chest pain. This was especially true with the recognition of nonsteroidal anti-inflammatory drug complications. Now, at the end of primary clinical practice, I believe I have found a satisfactory treatment. My […]

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Looking for Sarcopenia Biomarkers

Sarcopenia, defined as age-associated loss of skeletal muscle mass and function, has emerged as an important public health issue. It is associated with higher mortality, morbidity, physical disability, and health care cost.1, 2While sarcopenia should be diagnosed with measurements of muscle mass and function, serum biomarkers are needed for screening of sarcopenia in a large population. […]

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