Tag Archives: Featured

Geographic Variability in Liver Disease-Related Mortality Rates in the United States

Liver disease is an important cause of morbidity and mortality in the United States. Geographic variations in the burden of chronic liver disease may have significant impact on public health policies but have not been explored at the national level. The objective of this study is to examine interstate variability in liver disease mortality in […]

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Importance of Genetic Testing in the Diagnosis of Transthyretin Cardiac Amyloidosis

To the Editor: Systemic amyloidosis results from extracellular deposition of fibrillar material derived from aggregation of precursor proteins into insoluble beta-pleated sheets. The most frequently recognized types are due to prolonged inflammation, deposition of immunoglobulin light chains, and accumulation of transthyretin, a tetrameric protein synthesized in the liver. Transthyretin amyloidosis can occur owing to wild-type […]

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Vena Cava Compression Syndrome in Obesity is Reversed by Bariatric Surgery

To the Editor: Obesity is a major public health problem, with a prevalence of 10% to 20% in Western Europe.1 It is a risk factor for arterial hypertension, atherosclerosis, and heart failure.2 In times of rising prevalence in obesity, bariatric surgery offers an effective way to achieve weight loss.2 The indication for bariatric surgery is provided by interdisciplinary […]

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Medical Axioms: The Pithy Little Sayings That Reflect Deeper Knowledge

  I love axioms. Perhaps it is the result of hearing them from one of my earliest mentors in medical school. Or perhaps it is the result of advice given me by my journalist/English teacher mother who told me that everything you write can be improved by condensation. Whatever the underlying reason, I continue to […]

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Thoracoabdominal Aneurysm in a Professional Body Builder

To the Editor: A 33-year-old otherwise healthy man presented with worsening epigastric and flank pain for 3 weeks. He denied having vomiting, diarrhea, fever, urinary symptoms, or history of kidney stones. His vital signs were significant for a blood pressure of 140/72 mm Hg and pulse rate of 94 beats/min. Acute coronary syndrome was excluded by electrocardiography. A […]

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