Tag Archives: gangrene

One Thing after Another: Ecthyma Gangrenosum

Chronic high-dosage steroid therapy can pose a significant risk factor for infection due to its immunosuppressive effect. A 70-year-old African American man presented with acute bilateral painless vision loss. An investigative work-up produced a positive antinuclear antibody titer of 1:1280 with a speckled pattern, a positive test for anti-Ro/anti-Sjögren’s-syndrome-related antigen A antibody, and an erythrocyte […]

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Double Jeopardy: Autoimmune Myelofibrosis with Pyoderma Gangrenosum

A 33-year-old African American woman with no significant past medical history presented to an outside hospital with 3 months of oropharyngeal ulcers and odynophagia. She was also noted to be pancytopenic (hemoglobin 7.4 g/dL, mean corpuscular volume 81 fL, platelets 100,000/mm3, white blood cells 3000/mm3, absolute neutrophil count 600/mm3) with blood smear findings of teardrop […]

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Pyoderma Gangrenosum Associated with Acute Respiratory Distress Syndrome

To the Editor: Pyoderma gangrenosum is a rare neutrophilic dermatologic disorder that presents as painful necrotic ulcers. It can also involve the lungs and the kidneys. The etiology remains unclear. However, it has recently been reported that cytokines may play a key role in pyoderma gangrenosum’s pathogenesis. Similarly, acute respiratory distress syndrome is characterized as lethal […]

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Venous Gangrene

Venous Gangrene and Intravascular Coagulation and Fibrinolysis in a Patient Treated with Rivaroxaban A 67-year-old woman presented with new bilateral leg swelling and was diagnosed with bilateral deep vein thromboses. Rivaroxaban was started at 15 mg twice daily. Ten days later, the patient experienced increased right foot swelling, pain, and cyanosis (Figure). On admission, a right […]

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