Tag Archives: Rheumatology

Double Fixation: Bilateral Bisphosphonate-Related Hip Fractures

Bisphosphonates have been in use since the 1960s for the treatment of osteoporosis. They reduce bone resorption by inhibiting the action of osteoclast cells and also by inducing osteoclast apoptosis.1, 2 Since 2005, multiple studies have shown an increased prevalence of minimal-trauma subtrochanteric and diaphyseal femoral fractures in patients taking long-term bisphosphonate therapy.2, 3, 4, 5, 6, 7, 8, 9, 10 It is presumed that bisphosphonates […]

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Inside Out: Bone Marrow Necrosis and Fat Embolism

  Neurologic symptoms initially attributed to infection were ultimately the result of a devastating hematologic condition. The patient, a 57-year-old woman, was rushed to the emergency department for somnolence and slurred speech. She had experienced low back pain during the preceding week. Her medical history was notable for a ventriculoperitoneal shunt placed several years ago […]

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Progressive Collapse of the Thoracic Cage

A 48-year-old patient presented with severe and progressive painful shrinkage of the thoracic cage as the result of repetitive minor fractures. Chest radiographs showed a severe form of flail chest, and the lateral spine was overwhelmed by severe rigid scoliosis. At the age of 35 years and because of repetitive episodes of vertebral fractures and […]

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Rheumatoid Arthritis Presenting as Acute Myopericarditis

To the Editor: A 50-year-old man with hypertension, type 2 diabetes, gout, and treated latent tuberculosis infection presented to the Emergency Department with 12 hours of angina pectoris. Initial evaluation for acute coronary syndrome and pulmonary embolism were negative. However, 20 hours after hospital admission the patient developed substernal chest pain, 1-mm ST-segment elevation in […]

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Objectively Measured Physical Activity and Symptoms Change in Knee Osteoarthritis

  The study objective was to quantify the association between daily physical activity measured by accelerometer and 1-year changes in symptoms among people with knee osteoarthritis. Methods Participants from the Osteoarthritis Initiative had knee radiographs and physical activity assessed using GT1M ActiGraph (Pensacola, FL) uniaxial accelerometers at the 48-month visit. Physical activity was calculated and […]

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