Tag Archives: statins

2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?

The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the treatment of blood cholesterol recommends moderate- to high-intensity statins for patients with atherosclerotic cardiovascular disease but departs from the traditional treat-to-target approach. Whether percent low-density lipoprotein cholesterol (LDL-C) reduction or attained LDL-C levels add incremental prognostic value to statin dose is not […]

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Grapefruit Juice and Statins

Should patients avoid grapefruit juice consumption while taking widely used statins? A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin […]

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Joseph S. Alpert, MD

New Research: Stroke Rates Fall by 40% (video)

Incident strokes in the Medicare population fell by nearly 40% over the last 2 decades, a greater-than-expected decline. Check out Trends in Stroke Rates, Risk, and Outcomes in the United States, 1988 to 2008 the July 2014 issue of The American Journal of Medicine to learn more.

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Statins Decrease the Occurrence of Venous Thromboembolism in Patients with Cancer

In addition to cholesterol-lowering effect, statins exhibit anti-thrombotic and anti-inflammatory properties, which may affect coagulation cascade. In cancer patients, the use of statins decreased the odds of developing venous thromboembolism, when compared with non-statins users. Abstract Background Recent data suggest a reduction in the occurrence of venous thromboembolism in select groups of patients who use […]

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Statin-induced Myopathy: Hypothesis About Randomized Evidence and Clinical Impressions

Myopathy refers to any muscle disease, myalgia to muscle aches or weakness without creatine kinase elevation, and myositis includes increased creatine kinase. Rhabdomyolysis includes marked creatine kinase elevations usually with brown urine and urinary myoglobin.(1) Statins confer statistically significant and clinically important reductions in myocardial infarction, stroke, and cardiovascular death.2 The class is well tolerated, […]

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