The American Journal of Medicine Blog

To derive and validate a single metric of activity tracking that associates with lower risk of cardiovascular disease mortality. Methods We derived an algorithm, Personalized Activity Intelligence (PAI), using the HUNT Fitness Study (n = 4631), and validated it in the general HUNT population (n = 39,298) aged 20-74 years. The PAI was divided into three sex-specific […]

We sought to evaluate whether exogenous testosterone therapy is associated with increased risk of serious cardiovascular events as compared with other treatments or placebo. Methods Study selection included randomized controlled trials (RCTs) and observational studies that enrolled men aged 18 years or older receiving exogenous testosterone for 3 or more days. The primary outcomes were […]

Hypertrophic cardiomyopathy was first recognized as a disease of obstruction to left ventricular outflow, hence, its early names and acronyms such as idiopathic hypertrophic subaortic obstruction. The nonobstructive subset of patients, incapable of developing mechanical impedance to left ventricular outflow at rest or with physiologic exercise, was initially recognized by the Braunwald group at the […]

For centuries, the mind–body relationship has been postulated. These findings suggest that depression and anxiety are not simply “in the mind.” They are real illnesses, like any other physical illnesses, and can negatively impact the entire body, including the cardiovascular system. Despite the abundance of investigation and demonstration of a clear relationship between mental health […]

Clinical features of resistant hypertension are described, and the importance of several risk factors undergoing clinical investigation and reappraisal are considered in this review. True resistant hypertension must be distinguished from apparent resistant hypertension, of which important causes include medication nonadherence, illicit drug use, and alcoholism. Ambulatory blood pressure monitoring should be considered to rule out […]

The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies. The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease. Statins have become the first line […]