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Coronary Artery Disease Among Postmenopausal Women

  Epidemiological studies have shown a higher risk of cardiovascular mortality associated with early menopause, but the relation between menopausal age and extent of coronary artery disease after menopause is unknown. We assessed the relation between menopausal age and extent of coronary disease in postmenopausal women with an acute coronary syndrome. Methods A prospective study […]

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Antithrombotic strategy by CHA2DS2-VASc score. DAP = dual antithrombotic therapy with 2 antiplatelet agents; OAC + AA = dual antithrombotic therapy with an oral anticoagulant plus 1 antiplatelet agent; TT = triple antithrombotic therapy (oral anticoagulation plus dual antiplatelet therapy).

Triple vs Dual Antithrombotic Therapy in Patients with AF & CAD

Background The role of triple antithrombotic therapy vs dual antithrombotic therapy in patients with both atrial fibrillation and coronary artery disease remains unclear. This study explores the differences in treatment practices and outcomes between triple antithrombotic therapy and dual antithrombotic therapy in patients with atrial fibrillation and coronary artery disease. Methods Using the Outcomes Registry […]

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Computed tomography scan of the chest in a 59-year-old woman on warfarin. This patient had a longstanding history of pulmonary embolism and no other vascular risk factors and had been treated with warfarin for 30 years. This scan shows significant calcification of the left anterior descending artery and the left and right bronchi.

Warfarin and Vascular Calcification

  The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that […]

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Coronary angiography images demonstrating severe ostial stenosis of the intermediate artery (A) treated successfully by coronary stenting (B). ECG demonstrating global ‘saddle shaped’ ST elevation consistent with pericarditis (C). Chest radiography showing bilateral pleural effusion (D).

Postcardiac Injury Syndrome: A Rare Complication of Elective Coronary Angioplasty

Postcardiac injury syndrome conventionally has been described after myocardial infarction or cardiac surgery, but it is an infrequent complication of endovascular procedures. We report an unusual case of postcardiac injury syndrome occurring immediately after elective angioplasty. A 58-year-old man attended our hospital (Northwick Park Hospital) for elective angiography for symptoms of exertional angina. He had […]

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Exercise and Risk of Coronary Artery Disease: The FIT Project

  Exercise treadmill testing was used to compare risk factors for coronary artery disease among those who use and who do not use pulmonary medication. Background In the general population, the exercise treadmill testing variables of lower resting heart rate, higher peak heart rate, and greater fitness have favorable prognosis for mortality. Patients with obstructive […]

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Treatment of Hypertension in Patients with Coronary Artery Disease.

The 2015 American Heart Association/American College of Cardiology/American Society of Hypertension Scientific Statement “Treatment of Hypertension in Patients with Coronary Artery Disease” is summarized in the context of a clinical case. The Statement deals with target blood pressures, and the optimal agents for the treatment of hypertension in patients with stable angina, in acute coronary […]

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