Archive | dermatology RSS feed for this section
(A) Skin impairment. Papulonodular skin lesions on the tip of the nose, from 3 to 10 mm, characteristic of sarcoidosis: firm, nonedematous, noninflammatory, nonpainful, nonpruriginous, with predominant facial involvement. (B) Endoscopic view (right nasal fossa) showing a major mucosae thickening. (C) Numerous uniform circumscribed nests of non-caseating granulomata which are characterized by the paucicity of lymphocytes and absence of necrosis.

Skin and Nasal Involvement: Look for Sarcoidosis!

  Sarcoidosis is a systemic, noncaseating, granulomatous disease affecting young adults between the ages of 25 and 40 years, most often of Black origin (35.5/100,000 vs 10.9 in the White population). Although the lower respiratory tract is affected in 90% of cases, ear, nose, and throat locations are very uncommon, with a prevalence varying between […]

Read more
The patient had hemifacial atrophy.

Gradually Transformed: Parry–Romberg Syndrome

Headaches commonly compel patients to seek medical attention. Migraine, tension headache, cluster headaches, rebound headaches from overuse of medication, headaches that occur as an adverse reaction to medication, and those associated with infection are typically included in the differential diagnosis, but sometimes, a rarer entity is encountered. This was true for a 44-year-old farmer from […]

Read more
Koplik's spots on the buccal mucosa. Measles was later confirmed by testing with anti-measles immunoglobulin-M antibodies.

Koplik’s Spots and Measles

To the Editor: Measles, one of the most transmissible diseases, is most contagious before rash manifestation. Search for the pathognomonic Koplik’s spots could be critical for the early diagnosis in this prodromal period. Case Description A 47-year-old man had high-grade fever with a peak temperature of 39.7°C, photophobia, rhinitis, and dry cough. On the fifth […]

Read more
The patient's right hand was covered with erythematous macules.

A Plethora of Pustules: Acute Generalized Exanthematous Pustulosis

The patient’s presentation suggested a number of serious dermatologic or infectious diseases, but in fact, a drug reaction was to blame for her symptoms. A 69-year-old woman with a history of chronic obstructive pulmonary disease was admitted to our hospital with a worsening rash. Four days earlier she presented to a different facility with a […]

Read more

Sweet’s Syndrome Mimicking Anti-Neutrophil Cytoplasmic Antibodies–Associated Vasculitis

  Sweet’s syndrome is a rare neutrophilic skin disorder. The antibodies against neutrophil cytoplasmic antigens are called anti-neutrophil cytoplasmic antibodies (ANCAs). Positivity for ANCA has been reported in some nonvasculitic inflammatory disorders, including Sweet’s syndrome.1, 2 Here we report a case of myeloperoxidase (MPO)-ANCA– and (proteinase 3) (PR3)-ANCA–positive Sweet’s syndrome presenting unusual and severe purpuras. A 41-year-old […]

Read more
After the patient completed antibiotic therapy for ecthyma gangrenosum, the characteristic eschar remained a while longer.

One Thing after Another: Ecthyma Gangrenosum

Chronic high-dosage steroid therapy can pose a significant risk factor for infection due to its immunosuppressive effect. A 70-year-old African American man presented with acute bilateral painless vision loss. An investigative work-up produced a positive antinuclear antibody titer of 1:1280 with a speckled pattern, a positive test for anti-Ro/anti-Sjögren’s-syndrome-related antigen A antibody, and an erythrocyte […]

Read more
UA-42320404-1