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Hemoglobin A1c trend before and after proprotein convertase subtilisin/kexin 9 inhibitor (PCSK9I) therapy. Hemoglobin A1c values prior to PCSK9I therapy were in the range of 6.4% to 7.3%. After initiation of therapy, they slowly trended up, eventually doubled, and then improved after discontinuation of the medication.

Doubling of Hemoglobin A1c on PCSK9 Inhibitor Therapy

A 70-year-old man with history of cerebrovascular accident, hyperlipidemia, and type 2 diabetes mellitus presented with polyuria, polydipsia, and weight loss. Severe hyperglycemia (serum glucose, 585 mg/dL) was present on admission. No precipitating factors were identified. Initial laboratory findings were also notable for elevated aspartate aminotransferase (703 IU/L) and alanine aminotransferase (779 IU/L). Diabetes mellitus, […]

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Does #Marijuana Make You Skinny?

Google “Does Marijuana make you skinny?” and you’ll find a plethora of news articles like this one in The Atlantic: Study: Why Pot Smokers Are Skinnier  What is the science behind marijuana and metabolism? The American Journal of Medicine has published two research articles that showed regular marijuana usage boosts metabolism and helps people maintain […]

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CME Module: Insulin Therapy

A new CME module is available on The American Journal of Medicine website: Building a Solid Foundation in Diabetes: The Nuts and Bolts of Insulin Therapy.

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Body Weight, Insulin Resistance, and Serum Adipokine Levels 2 Years after 2 Types of Bariatric Surgery

Clinically severe obesity is associated with premature death and disability from heart disease and cancer. Gastric bypass surgery is an effective tool to induce sustained weight loss and normalization of metabolic parameters. Abstract Objective Bariatric surgery reverses obesity-related comorbidities, including type 2 diabetes mellitus. Several studies have already described differences in anthropometrics and body composition […]

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