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Historical figures in hypertrophic cardiomyopathy. Left: Mr. Claude Brady, the first patient identified clinically with hypertrophic cardiomyopathy at age 22 years, is now 80 years of age. Right: Dr. Eugene Braunwald, who diagnosed Mr. Brady and went on to develop the first clinical profile of this disease in the early 1960s.

Achieving Extended Longevity and Quality of Life for Senior Patients With Hypertrophic Cardiomyopathy

To read this article in its entirety please visit our website. – This article originally appeared in the November 2017 issue of The American Journal of Medicine.

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Magnetic resonance imaging of the head performed 5 days after a hypoxic episode demonstrated T2/fluid-attenuated inversion recovery (FLAIR) hyperintensities (A) with corresponding restricted diffusion on diffusion-weighted image (DWI) sequence (B) and apparent diffusion coefficient (ADC) sequence (C).

Delayed Transient Cortical Blindness from Hypoxic Ischemic Encephalopathy

To the Editor: An 85-year-old woman with no significant past medical history presented after a mechanical fall complicated by multiple fractures. She received intravenous pain medications with resultant decreased level of consciousness and respiratory distress. Intubation was difficult because of bilateral mandibular fractures, and she consequently experienced 10 minutes of hypoxia before secure airway control […]

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Choosing Wisely? Measuring the Burden of Medications in Older Adults (video)

The burden of medications near the end of life has recently come under scrutiny, because several studies suggested that people with life-limiting illness receive potentially futile treatments. Methods We identified 511,843 older adults (>65 years) who died in Sweden between 2007 and 2013 and reconstructed their drug prescription history for each of the last 12 […]

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Joseph S. Alpert, MD

Polypharmacy in Elderly Patients: The March Goes On and On

Polypharmacy is a major public health problem in the United States and abroad. Although there is no standard definition of polypharmacy, I see and recognize it every day in the outpatient and inpatient environment. A typical example that I saw yesterday was an 84-year-old man admitted to our internal medicine service for worsening heart failure. […]

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Comparison of predictive model variations by number of members identified as high-risk during validation (>20%). The number of people who actually fell within each model's estimated high-risk group are provided (in blue) and the number within each bar denotes the fraction of the high-risk members who fell, ie, positive predictive value.

Predicting Falls in People Aged 65 Years and Older from Insurance Claims

Accidental falls among people aged 65 years and older caused approximately 2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the US annually in recent years. Here, we derive and validate a predictive model for falls based on a retrospective cohort of those 65 years and older. Methods Insurance claims from a […]

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Training Geriatric Cardiologists for an Aging Population: Time to Get Going

Our society is aging—20% of the US population will be aged more than 65 years by 2030, and the number of the “oldest old,” those aged more than 85 years, will triple by 2050. Cardiovascular disease prevalence increases exponentially with age, and direct costs for cardiovascular care in the United States will exceed $800 billion […]

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