Tag Archives: Cholesterol
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A Reappraisal of the Lipid Hypothesis

The lipid hypothesis, which postulates that lowering serum cholesterol saves lives and prevents cardiovascular disease, has been supported by a prodigious volume of evidence over the past 30 years.1 Lowering low-density lipoprotein cholesterol (LDL-C) has become the foundation of cardiovascular disease prevention guidelines, yet not all of the evidence supports this recommendation.2 A reappraisal of the lipid […]

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Density plots comparing high-density lipoprotein cholesterol (HDL-C) at baseline in Systolic Blood Pressure Intervention Trial (SPRINT) participants who developed hyponatremia (red) during the study and patients who did not develop hyponatremia (blue). Baseline HDL-C was significantly more elevated in participants who later developed hyponatremia, for both males and females (P <.0001 in both sexes; Wilcoxon test).

Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients

  Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. Our objective in this study was to identify risk […]

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The Impact of Cardiorespiratory Fitness Levels on the Risk of Developing Atherogenic Dyslipidemia

  Low cardiorespiratory fitness has been established as a risk factor for cardiovascular-related morbidity. However, research about the impact of fitness on lipid abnormalities, including atherogenic dyslipidemia, has produced mixed results. The purpose of this investigation is to examine the influence of baseline fitness and changes in fitness on the development of atherogenic dyslipidemia. Methods […]

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CME: LDL Cholesterol Lowering: How & How Low?

The American Journal of Medicine website has posted a new continuing medical education module on lowering cholesterol. LDL Cholesterol Lowering: How and How Low? Program Overview The latest American College of Cardiology/American Heart Association lipid management guidelines make two general statements: 1) that elevated LDL cholesterol levels should be treated with the drug class proven […]

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Reduction in Percent LDL Cholesterol or Attained LDL-C Levels or Both?

The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies. The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease. Statins have become the first line […]

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Major cardiovascular events in the cohort with attained LDL-C >70 mg/dL as a function of percent LDL-C reduction. LDL = low-density lipoprotein.

2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?

The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the treatment of blood cholesterol recommends moderate- to high-intensity statins for patients with atherosclerotic cardiovascular disease but departs from the traditional treat-to-target approach. Whether percent low-density lipoprotein cholesterol (LDL-C) reduction or attained LDL-C levels add incremental prognostic value to statin dose is not […]

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