Tag Archives: Clinical Research
Density plots comparing high-density lipoprotein cholesterol (HDL-C) at baseline in Systolic Blood Pressure Intervention Trial (SPRINT) participants who developed hyponatremia (red) during the study and patients who did not develop hyponatremia (blue). Baseline HDL-C was significantly more elevated in participants who later developed hyponatremia, for both males and females (P <.0001 in both sexes; Wilcoxon test).

Elevated High-Density Lipoprotein Cholesterol Is Associated with Hyponatremia in Hypertensive Patients

  Recently, the Systolic Blood Pressure Intervention Trial (SPRINT) showed that intensive lowering of systolic blood pressure is beneficial, but is associated with more adverse events. Hyponatremia was notably more frequent in the intensive treatment group. Investigating its risk factors is crucial for preventing this complication. Our objective in this study was to identify risk […]

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A Deficiency of Nutrition Education and Practice in Cardiology

Nutrition is one of the foundations of cardiovascular guidelines for risk reduction and treatment. However, little is known about whether cardiologists, cardiology fellows-in-training, and cardiovascular team members have the nutrition education and knowledge necessary to implement these guidelines. The aim of this study was to describe the educational experiences, attitudes, and practices relating to nutrition […]

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High-Value, Cost-Conscious Care: Iterative Systems-Based Interventions to Reduce Unnecessary Laboratory Testing

Inappropriate testing contributes to soaring healthcare costs within the United States, and teaching hospitals are vulnerable to providing care largely for academic development. Via its “Choosing Wisely” campaign, the American Board of Internal Medicine recommends avoiding repetitive testing for stable inpatients. We designed systems-based interventions to reduce laboratory orders for patients admitted to the wards […]

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Hepatocellular Carcinoma Screening Associated with Early Tumor Detection and Improved Survival Among Patients with Cirrhosis in the US

Professional societies recommend hepatocellular carcinoma screening in patients with cirrhosis, but high-quality data evaluating its effectiveness to improve early tumor detection and survival in “real world” clinical practice are needed. We aim to characterize the association between hepatocellular carcinoma screening and early tumor detection, curative treatment, and overall survival among patients with cirrhosis. Methods We […]

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Choosing Wisely? Measuring the Burden of Medications in Older Adults (video)

The burden of medications near the end of life has recently come under scrutiny, because several studies suggested that people with life-limiting illness receive potentially futile treatments. Methods We identified 511,843 older adults (>65 years) who died in Sweden between 2007 and 2013 and reconstructed their drug prescription history for each of the last 12 […]

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Comparison of predictive model variations by number of members identified as high-risk during validation (>20%). The number of people who actually fell within each model's estimated high-risk group are provided (in blue) and the number within each bar denotes the fraction of the high-risk members who fell, ie, positive predictive value.

Predicting Falls in People Aged 65 Years and Older from Insurance Claims

Accidental falls among people aged 65 years and older caused approximately 2,700,000 injuries, 27,000 deaths, and cost more than 34 billion dollars in the US annually in recent years. Here, we derive and validate a predictive model for falls based on a retrospective cohort of those 65 years and older. Methods Insurance claims from a […]

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