Tag Archives: gangrene
After the patient completed antibiotic therapy for ecthyma gangrenosum, the characteristic eschar remained a while longer.

One Thing after Another: Ecthyma Gangrenosum

Chronic high-dosage steroid therapy can pose a significant risk factor for infection due to its immunosuppressive effect. A 70-year-old African American man presented with acute bilateral painless vision loss. An investigative work-up produced a positive antinuclear antibody titer of 1:1280 with a speckled pattern, a positive test for anti-Ro/anti-Sjögren’s-syndrome-related antigen A antibody, and an erythrocyte […]

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Bone marrow biopsy showing increased reticulin fibrosis: hematoxylin and eosin (H&E) ×100 (A), H&E ×200 (B), and reticulin ×200 (C). Peripheral blood smear showing anisopoikilocytosis and occasional teardrop cells (D).

Double Jeopardy: Autoimmune Myelofibrosis with Pyoderma Gangrenosum

A 33-year-old African American woman with no significant past medical history presented to an outside hospital with 3 months of oropharyngeal ulcers and odynophagia. She was also noted to be pancytopenic (hemoglobin 7.4 g/dL, mean corpuscular volume 81 fL, platelets 100,000/mm3, white blood cells 3000/mm3, absolute neutrophil count 600/mm3) with blood smear findings of teardrop […]

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Clinical manifestations of the left lower extremity, and X-ray and computed tomography images of the chest. (A) Painful deep ulcers with necrotic tissue and diffuse erosive purpura. (B) A butterfly shadow indicating pulmonary edema. (C) Ground-glass opacity and infiltrative shadows around bilateral hilar regions, thickening of interlobular septa, and bilateral pleural effusions are observed. (D) After methylprednisolone pulse treatment, the ulcers expanded with massive necrotic tissue. (E) After 11 months of treatment the ulcers have fully healed, with distinguishable scars reaching the muscles.

Pyoderma Gangrenosum Associated with Acute Respiratory Distress Syndrome

To the Editor: Pyoderma gangrenosum is a rare neutrophilic dermatologic disorder that presents as painful necrotic ulcers. It can also involve the lungs and the kidneys. The etiology remains unclear. However, it has recently been reported that cytokines may play a key role in pyoderma gangrenosum’s pathogenesis. Similarly, acute respiratory distress syndrome is characterized as lethal […]

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Venous gangrene of the right lower extremity. Image taken on day of admission.

Venous Gangrene

Venous Gangrene and Intravascular Coagulation and Fibrinolysis in a Patient Treated with Rivaroxaban A 67-year-old woman presented with new bilateral leg swelling and was diagnosed with bilateral deep vein thromboses. Rivaroxaban was started at 15 mg twice daily. Ten days later, the patient experienced increased right foot swelling, pain, and cyanosis (Figure). On admission, a right […]

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