Tag Archives: sarcoidosis
Hematoxylin-eosin stain showing patchy perivascular and interstitial granulomas (original magnification, 40×).

Sarcoidosis Presenting as Isolated Anasarca and Hypercalcemia

A 62-year-old woman presented to clinic for a second evaluation. Previously healthy, she initially presented for care several months earlier with anasarca. Initial workup was notable for normal renal function, calcium level, and liver function tests, no proteinuria, and echocardiogram demonstrating mild diastolic dysfunction and concentric left ventricular hypertrophy but preserved systolic function. One month […]

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A, Single variably hypopigmented papule over the left upper eye. B, Multiple hyperpigmented maculopapular rash over the neck. C, Magnetic resonance imaging of the lumbosacral spine reveals a mottled appearance of the bone marrow on the T1-weighted images. D, CT scan of the chest reveals multiple scattered nodules over both lung fields uniformly distributed without any zonal preference. E, Multiple similar-appearing noncaseating epithelioid granulomas were observed on bone marrow biopsy.

The Great Masquerader Strikes Again!

To the Editor: A 42-year-old man presented with symptoms of severe low-back pain that was aggravated by activity and bending. He also reported sharp pains radiating down the back of the right thigh. In addition, he had an occasional mild cough with yellowish-gray sputum production. He denied any weight loss, night sweats, fevers, or chills. […]

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Axial (A), coronal (C), and parasagittal (D) computed tomography chest maximal intensity projections revealed innumerable spiculated soft-tissue nodules throughout the lungs, varying in size from 1 to 20 mm. Although the majority are centrilobular, there are some based on the pleura and within fissures, highlighted in the parasagittal slice (D). They are well defined and not typical of hypersensitivity pneumonitis. The nodules were variably avid on positron emission tomography scan (B).

Necrotizing Sarcoid Granulomatosis: Clinico-Radio-Pathologic Diagnosis

A 30-year-old man was referred to the rheumatology outpatient department and seen urgently after developing diplopia over a 4- to 8-hour period and an isolated left fourth cranial nerve palsy associated with a bifrontal and left temporal headache and episodic vertigo. Magnetic resonance imaging of the brain at that time was unremarkable. The following week […]

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The third portion of the duodenum: flattened folds.

Screening of Celiac Disease in Patients With Sarcoidosis?

Sarcoidosis and celiac disease (CD) are both autoimmune disorders, which have been associated with class II haplotype HLA-DR3, DQ2. Literature demonstrates this combination is more prevalent in the Irish population.1 Celiac disease is caused by the ingestion of gluten, where the predisposed population (HLA BQ2 or BQ8 carriers) develop antibodies against gluten peptides. The prevalence of […]

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