{"id":4355,"date":"2017-09-06T06:28:50","date_gmt":"2017-09-06T13:28:50","guid":{"rendered":"https:\/\/amjmed.org\/?p=4355"},"modified":"2017-09-14T17:23:21","modified_gmt":"2017-09-15T00:23:21","slug":"optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials","status":"publish","type":"post","link":"https:\/\/amjmed.org\/optimal-systolic-blood-pressure-target-after-sprint-insights-from-a-network-meta-analysis-of-randomized-trials\/","title":{"rendered":"Transverse Lines of the Nails"},"content":{"rendered":"<figure id=\"attachment_4359\" aria-describedby=\"caption-attachment-4359\" style=\"width: 300px\" class=\"wp-caption aligncenter\"><a href=\"https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?ssl=1\"><img data-recalc-dims=\"1\" loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-4359\" src=\"https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?resize=300%2C151&#038;ssl=1\" alt=\"Transverse lines of the fingernails. (A) Beau's lines (arrows) of the thumbnail. (B) Mees' lines (arrowheads) of the thumbnail.\" width=\"300\" height=\"151\" srcset=\"https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?resize=300%2C151&amp;ssl=1 300w, https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?resize=696%2C351&amp;ssl=1 696w, https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?w=763&amp;ssl=1 763w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><figcaption id=\"caption-attachment-4359\" class=\"wp-caption-text\">Transverse lines of the fingernails. (A) Beau&#8217;s lines (arrows) of the thumbnail. (B) Mees&#8217; lines (arrowheads) of the thumbnail.<\/figcaption><\/figure>\n<p>Four distinct, transverse, depressed lines (<a id=\"back-gr1\" class=\"figureLink\" style=\"color: #336699;\" href=\"http:\/\/www.amjmed.com\/cms\/attachment\/2094931985\/2077371647\/gr1.jpg\" target=\"_blank\" data-link=\"modal\" data-target=\"#image-S0002934317300049gr1\" data-class=\"largeImg\">Figure, A<\/a>) developed on the fingernails of a 73-year-old man with castration-resistant prostate cancer after 4 cycles of docetaxel-based chemotherapy; the lines were parallel and evenly spaced (Beau&#8217;s lines). Three transverse white bands (<a id=\"back-gr1\" class=\"figureLink\" style=\"color: #336699;\" href=\"http:\/\/www.amjmed.com\/cms\/attachment\/2094931985\/2077371647\/gr1.jpg\" target=\"_blank\" data-link=\"modal\" data-target=\"#image-S0002934317300049gr1\" data-class=\"largeImg\">Figure, B<\/a>) appeared on the fingernails of a 62-year-old woman with recurrent metastatic soft tissue sarcoma after 3 cycles of chemotherapy with vincristine, ifosfamide, and doxorubicin; the nail surfaces were smooth, and the bands did not fade with digital compression (Mees&#8217; lines).<\/p>\n<div class=\"floatDisplay\">Transverse lines of the nails can be caused by a growth arrest in the nail matrix or changes in the color of the nail itself, and may suggest underlying systemic conditions or the effects of a toxin or drug.<span class=\"bibRef\"><span id=\"back-bib1\" class=\"layerTrigger layerTriggerClick\">1<\/span><\/span>,\u00a0<span class=\"bibRef\"><span id=\"back-bib2\" class=\"layerTrigger layerTriggerClick\">2<\/span><\/span>\u00a0Beau&#8217;s lines are a typical sign of acute toxicity to nail matrix keratinocytes, resulting in a transient arrest in nail plate production. The nail develops a transverse linear depression that moves distally as the nail grows.<span class=\"bibRef\"><span id=\"back-bib3\" class=\"layerTrigger layerTriggerClick\">3<\/span><\/span>\u00a0In Mees&#8217; lines, change occurs in the color of the nail without the cessation of nail matrix growth. Mees&#8217; lines are easily differentiated from Muehrcke&#8217;s lines, which are apparent leukonychia and paired white lines caused by vascular congestion in the nail\u00a0bed, because Muehrcke&#8217;s lines fade with digital compression.<span class=\"bibRef\"><span id=\"back-bib2\" class=\"layerTrigger layerTriggerClick\">2<\/span><\/span>,\u00a0<span class=\"bibRef\"><span id=\"back-bib4\" class=\"layerTrigger layerTriggerClick\">4<\/span><\/span>\u00a0An adverse reaction resulting from chemotherapeutic agents should be considered when transverse lines are seen on the nails, including Beau&#8217;s lines and Mees&#8217; lines.<\/div>\n<p>To read this article in its entirety please visit our<a title=\"Transverse Lines of the Nails\" href=\"http:\/\/www.amjmed.com\/article\/S0002-9343(17)30004-9\/fulltext\" target=\"_blank\">\u00a0website.<\/a><\/p>\n<p>-Ik-Chan Song, MD, Hyo Jin Lee, MD, PhD<\/p>\n<p>This article originally appeared in the\u00a0<a title=\"June 2017 Issue\" href=\"http:\/\/www.amjmed.com\/issue\/S0002-9343(16)X0019-8\" target=\"_blank\">June\u00a02017<\/a>\u00a0issue\u00a0of<em><strong>\u00a0The American Journal of Medicine.<\/strong><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Four distinct, transverse, depressed lines (Figure, A) developed on the fingernails of a 73-year-old man with castration-resistant prostate cancer after 4 cycles of docetaxel-based chemotherapy; the lines were parallel and evenly spaced (Beau&#8217;s lines). Three transverse white bands (Figure, B) appeared on the fingernails of a 62-year-old woman with recurrent metastatic soft tissue sarcoma after [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":4359,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"advanced_seo_description":"","jetpack_seo_html_title":"","jetpack_seo_noindex":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[74,103],"tags":[362,368,727],"class_list":{"0":"post-4355","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-dermatology","8":"category-fingernails","9":"tag-dermatology-2","10":"tag-finger-nails","11":"tag-toxicity"},"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/amjmed.org\/wp-content\/uploads\/2017\/09\/gr1.jpg?fit=763%2C385&ssl=1","jetpack_sharing_enabled":true,"jetpack_likes_enabled":true,"_links":{"self":[{"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/posts\/4355","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/comments?post=4355"}],"version-history":[{"count":0,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/posts\/4355\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/media\/4359"}],"wp:attachment":[{"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/media?parent=4355"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/categories?post=4355"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/amjmed.org\/wp-json\/wp\/v2\/tags?post=4355"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}