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CardiologyFool Me Once, Fool Me Twice

Fool Me Once, Fool Me Twice

Initial echocardiographic images were obtained. (A) Transthoracic echocardiography (TTE) in a parasternal long axis view identified significant left ventricular hypertrophy and a thickened interventricular septum (1.65 cm). (B) This transesophageal echocardiography (TEE) view showed systolic anterior motion of the anterior leaflet of the mitral valve in the left ventricular outflow tract. (C) When enhanced with color Doppler imaging, the same TEE view as shown in B demonstrated turbulent aliased flow across the left ventricular outflow tract. (D) Apical 5-chamber TTE color Doppler imaging disclosed turbulent flow across the left ventricular outflow tract during systole.
Initial echocardiographic images were obtained. (A) Transthoracic echocardiography (TTE) in a parasternal long axis view identified significant left ventricular hypertrophy and a thickened interventricular septum (1.65 cm). (B) This transesophageal echocardiography (TEE) view showed systolic anterior motion of the anterior leaflet of the mitral valve in the left ventricular outflow tract. (C) When enhanced with color Doppler imaging, the same TEE view as shown in B demonstrated turbulent aliased flow across the left ventricular outflow tract. (D) Apical 5-chamber TTE color Doppler imaging disclosed turbulent flow across the left ventricular outflow tract during systole.

A thorough evaluation suggested the patient’s initial diagnosis was not quite right; but it was not wrong, either. An 83-year-old woman with presumed aortic stenosis was referred to our medical center for aortic valve replacement. She first presented at another facility with a 3-month history of worsening shortness of breath, particularly on exertion. Whereas she had once been able to walk 3 miles without effort, she was now winded after 1 block.

The patient denied syncope, orthopnea, paroxysmal nocturnal dyspnea, lower extremity edema, or significant weight change. A left heart angiogram showed a hyperdynamic left ventricle, and coronary angiography demonstrated a stable 50% ostial left anterior descending lesion. Hemodynamic measurements detected a mean gradient from the left ventricle to the aorta of 31 mmHg; the aortic valve area was calculated as 0.8 sq cm.

To find out the diagnosis, read the full article here.

– Christopher Vanichsarn, MD, Robert James Siegel, MD

This article originally appeared in the October 2015 issue of The American Journal of Medicine.

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