Thursday, November 21, 2024
Subscribe American Journal of Medicine Free Newsletter
Patient CareCase StudiesRoundup Intoxication

Roundup Intoxication

Herbicide Roundup Intoxication: Successful Treatment with Continuous Renal Replacement Therapy

Roundup (Monsanto Corporation, St. Louis, Mo) is a commercial herbicide containing glyphosate and surfactant, used primarily for killing weeds. Its key component, glyphosate, is a competitive inhibitor of the shikimate pathway, a metabolic pathway found only in plants.1 However, serious intoxication, including lethal cases by ingestion of Roundup, has been reported, with a mortality rate of 7%-30%.2, 3, 4 We describe a patient with a near-lethal case of Roundup intoxication with multiorgan system failure who recovered after continuous renal replacement therapy.

A 66-year-old Hispanic man with a history of non-insulin-dependent diabetes, hypertension, and alcohol abuse was brought to the Emergency Department unconscious after having ingested approximately 500 mL of rum and 350 mL of Roundup. He was in an argument with his wife and was purported to have gone to the shed in his backyard and accidentally mixed up his alcohol with Roundup. Approximately 2 hours later he was found to have altered mental status, an episode of non-bloody, non-bilious emesis, and was more difficult to arouse.

To read this article in its entirety, please visit our website.

— Billy T. Hour, MD, Cary Belen, DO, Tausif Zar, MD, Yeong-Hau H. Lien, MD, PhD

This article originally appeared in the August 2012 issue of The American Journal of Medicine.

Latest Posts

lupus

Sarcoidosis with Lupus Pernio in an Afro-Caribbean Man

A 54-year-old man of Afro-Caribbean ancestry presented with a 2-month history of nonproductive cough, 10-day history of constant subjective fevers, and a 1-day history...
Flue Vaccine

Flu Vaccination to Prevent Cardiovascular Mortality (video)

0
"Influenza can cause a significant burden on patients with coronary artery disease," write Barbetta et al in The American Journal of Medicine. For this...
varicella zoster

Varicella Zoster Virus-Induced Complete Heart Block

0
Complete heart block is usually caused by chronic myocardial ischemia and fibrosis but can also be induced by bacterial and viral infections. The varicella...
Racial justice in healthcare

Teaching Anti-Racism in the Clinical Environment

0
"Teaching Anti-Racism in the Clinical Environment: The Five-Minute Moment for Racial Justice in Healthcare" was originally published in the April 2023 issue of The...
Invisible hand of the market

The ‘Invisible Hand’ Doesn’t Work for Prescription Drugs

0
Pharmaceutical innovation has been responsible for many “miracles of modern medicine.” Reliance on the “invisible hand” of Adam Smith to allocate resources in the...
Joseph S. Alpert, MD

New Coronary Heart Disease Risk Factors

0
"New Coronary Heart Disease Risk Factors" by AJM Editor-in Chief Joseph S. Alpert, MD was originally published in the April 2023 issue of The...
Cardiovascular risk from noncardiac activities

Cardiac Risk Related to Noncardiac & Nonsurgical Activities

0
"Assessment of Cardiovascular Risk for Noncardiac and Nonsurgical Activities" was originally published in the April 2023 issue of The American Journal of Medicine. Cardiovascular risk...