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Patient CareCase StudiesIt Is Not Pneumonia! A Case of Unilateral Pulmonary Edema

It Is Not Pneumonia! A Case of Unilateral Pulmonary Edema

(A) Right upper and lower lobes air space opacities on admission chest X-ray. (B) Near-complete resolution of the right lung opacities on a follow-up chest X-ray 72 hours later.
A 65-year-old woman with a past medical history of diabetes and chronic obstructive pulmonary disease presented with a 3-day history of shortness of breath and mostly dry cough.
She was tachypneic, tachycardic, and afebrile on admission, and her oxygen saturation was 82% on room air. There were bilateral crackles and expiratory wheezes but no murmurs or gallop on auscultation and no pedal edema. The chest radiograph (CXR) was reported to have air space opacities in the right upper and lower lobes. (Figure A) She had leukocytosis of 13.0 K/mL3, and an electrocardiogram revealed atrial fibrillation. Bilevel positive airway pressure, ceftriaxone, azithromycin, and bronchodilators were started. The patient was admitted as a case of community-acquired pneumonia.

The absence of fever, presence of cardiomegaly on CXR, and an elevated N-terminal pro B-natriuretic peptide level of 8800 pg/mL raised doubt about pneumonia as the sole cause of this presentation. We administered 160 mg of intravenous frusemide over 12 hours for a working diagnosis of unilateral pulmonary edema secondary to heart failure, which resulted in rapid improvement of respiratory status and oxygenation. She was able to breathe without the need for bilevel positive airway pressure after 48 hours. The blood culture and the sputum bacterial and viral cultures did not show any growth. A follow-up CXR 72 hours after admission revealed near-complete resolution of the right lung opacities, which made the diagnosis of pneumonia unlikely because pulmonary opacities secondary to pneumonia take weeks to resolve. (Figure B) The echocardiogram showed global hypokinesia, an ejection fraction of 25%, a severely dilated left atrium, and only mild mitral regurgitation. These findings supported the diagnosis of heart failure as the cause of this presentation.

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-Facundo E. Stingo, MD, Tariq Sallam, MD, Rukma Govindu, MD, Hussam Ammar, MD

This article originally appeared in the September 2020 issue of The American Journal of Medicine

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