Archive | Warfarin RSS feed for this section
variety of pills and medications

Improving Warfarin Management Within the Medical Home: A Health-System Approach

Anticoagulation clinics have been considered the optimal strategy for warfarin management with demonstrated improved patient outcomes through increased time in therapeutic international normalized ratio (INR) range, decreased critical INR values, and decreased anticoagulation-related adverse events. However, not all health systems are able to support a specialized anticoagulation clinic or may see patient volume exceed available […]

Read more
measuring belly fat with calipers

Impact of Body Mass Index and Genetics on Warfarin Major Bleeding Outcomes in a Community Setting

Several studies have demonstrated an association between body mass index (BMI) and warfarin therapeutic dose, but none evaluated the association of BMI with the clinically important outcome of major bleeding in a community setting. To address this evidence gap, we conducted a case–control study to evaluate the association between BMI and major bleeding risk among […]

Read more
Computed tomography scan of the chest in a 59-year-old woman on warfarin. This patient had a longstanding history of pulmonary embolism and no other vascular risk factors and had been treated with warfarin for 30 years. This scan shows significant calcification of the left anterior descending artery and the left and right bronchi.

Warfarin and Vascular Calcification

  The vitamin K antagonist, warfarin, is the most commonly prescribed oral anticoagulant. Use of warfarin is associated with an increase in systemic calcification, including in the coronary and peripheral vasculature. This increase in vascular calcification is due to inhibition of the enzyme matrix gamma-carboxyglutamate Gla protein (MGP). MGP is a vitamin K-dependent protein that […]

Read more
white tablets spilling out of a pill bottle

Warfarin Dosing Algorithms and the Need for Human Intervention

Dosing algorithms for warfarin incorporate clinical and genetic factors, but human intervention to overrule algorithm-based dosing may occasionally be required. The frequency and reasons for varying from algorithmic warfarin management have not been well studied. Methods We analyzed a prospective cohort of 1015 participants from the Clarification of Optimal Anticoagulation through Genetics trial who were […]

Read more
Nonhealing ulcers

Nonhealing Ulcers

A Surfeit of Possibilities… Precise diagnosis of lower-extremity ulcerations is essential. Management differs so extensively between etiologies that misdiagnosis can lead to fatal outcomes. This was brought to mind when an 89-year-old woman was admitted directly to the hospital for treatment of worsening bilateral lower-extremity ulcerations. She had been transferred from another institution after a […]

Read more

March 2012: Warfarin & Bleeding

In this video, AJM Editor-in-Chief Joseph S. Alpert, MD reviews Safety of Arthrocentesis and Joint Injection in Patients Receiving Anticoagulation at Therapeutic Levels in the March 2012 issue of The American Journal of Medicine.

Read more