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Appropriate Use of D-dimer in Hospital Patients

D-dimer, the final product of plasmin-mediated degradation of fibrin-rich thrombi, has emerged as a simple blood test that can be used in diagnostic algorithms for the exclusion of venous thromboembolism. D-dimer also is used as a part of the diagnostic tests for disseminated intravascular coagulation, where excessive thrombin generation is the key pathophysiological factor. However, […]

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D-dimer Testing in Patients with Suspected Pulmonary Embolism and Impaired Renal Function

The specificity of D-dimer testing in patients with suspected pulmonary embolism and impaired renal function is significantly decreased. Nonetheless, performing D-dimer tests is still useful because computed tomography scanning can be withheld in a significant proportion of these patients. Abstract Background Determination of pretest probability and D-dimer tests are the first diagnostic steps in patients […]

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