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Should Patients Infected with Borrelia burgdorferi No Longer Be Referred to as Having Lyme Disease?

In 1977, a seminal paper described what was subsequently called Lyme arthritis.1 The name ‘Lyme’ originated from the initial investigation of the disease that was conducted in the Connecticut towns of Lyme, Old Lyme, and East Haddam.1 As more of the clinical manifestations of this illness were discovered, the condition became referred to as Lyme disease.2, 3, 4 In 1983, the […]

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Ixodes scapularis, the primary vector of Lyme disease in eastern North America. (Image Credit: Public Library of Science, Wiki CC License.)

Straight Talk About Chronic Lyme Disease

Four years ago, we noted an example of irresponsible reporting on Lyme disease by an investigative television news team.1 Consequently, when we learned that this same group was airing a new 5-part series entitled, “The Lyme Wars: Investigating a Public Health Crisis,” we were most interested to see if they had done a better job this […]

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(A) Twelve-lead electrocardiogram with first-degree heart block. (B) Transthoracic echocardiogram stills depicting moderate mitral and tricuspid regurgitation. (C) T1-weighted, gadolinium-enhanced brain magnetic resonance imaging with abnormal enhancement of the right facial nerve (arrow). LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle.

Hints of Lyme: Disseminated Borreliosis Involving the Mitral and Tricuspid Valves

A 33-year-old man with cystic fibrosis 220 days removed from bilateral lung transplantation presented with 1 week of intermittent fevers (maximum 102°F), malaise, bilateral lower extremity edema, unintentional weight gain (8 pounds), and 2 days of dyspnea on exertion. His posttransplant course was complicated by persistent leukopenia with intermittent neutropenia attributed to his antirejection regimen of […]

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Ixodes scapularis, the primary vector of Lyme disease in eastern North America. (Image Credit: Public Library of Science, Wiki CC License.)

The Clinical Relevance of Studies on Borrelia burgdorferi Persisters

In North America, Lyme disease is principally caused by Borrelia burgdorferi sensu stricto, hereafter referred to as “B. burgdorferi.” It is acquired by the bite of an infected Ixodes tick. The most common clinical manifestation is a skin lesion, referred to as “erythema migrans,” which is due to cutaneous infection with B. burgdorferi. Other objective manifestations may involve the nervous […]

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Ixodes scapularis, the primary vector of Lyme disease in eastern North America. (Image Credit: Public Library of Science, Wiki CC License.)

False and Misleading Information About Lyme Disease

  Recently, there has been considerable interest in the topic of fake news. For infectious diseases physicians, false and misleading information about the diagnosis and treatment of Lyme disease is not new. It is increasing in frequency and prominence, creating much confusion among primary care physicians and their patients. Persistent, unexplained subjective symptoms such as […]

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Ixodes scapularis, the primary vector of Lyme disease in eastern North America. (Image Credit: Public Library of Science, Wiki CC License.)

Post-Lyme Disease Symptoms Revisited

On the Internet, in the halls of academia, and on self-help television shows, the chronic Lyme disease battle rages on. In March 2013 issue, The American Journal of Medicine published Common Misconceptions About Lyme Disease by Halperin et al. This review– as the title suggests– carefully outlines misconceptions about Lyme disease and explains the research and […]

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