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Fatty and nodular tissue from an extratesticular germ cell tumor of the anterior mediastinum infiltrating the thymus gland. Histopathologic examination of the excised mediastinal tissue revealed a mixed primarily seminomatous (95%) with minor teratomatous (5%) component germ cell tumor in the background thymic tissue.

Hypertestosteronemia and Infertility from a Mediastinal Extragonadal Germ Cell Tumor

Extragonadal germ cell tumors are tumors of gonadal origin representing less than 5% of germ cell malignancies that form outside gonads. These are typically found in the mediastinum, retroperitoneum, or pineal gland. A 26-year-old man presented to the infertility clinic in January 2016 with a 2-year history of infertility. He had known hypertrophic cardiomyopathy due […]

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Risk of bias assessment of the included randomized controlled trials using the Cochrane Risk of Bias Tool.

Cardiovascular Risks of Exogenous Testosterone Use Among Men (videos)

We sought to evaluate whether exogenous testosterone therapy is associated with increased risk of serious cardiovascular events as compared with other treatments or placebo. Methods Study selection included randomized controlled trials (RCTs) and observational studies that enrolled men aged 18 years or older receiving exogenous testosterone for 3 or more days. The primary outcomes were […]

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Muscle mass loss estimated by using mixed-effect models analysis adjusted for age according to the investigated risk factors: (A) leisure physical activity (dotted line: ≥15 h/wk, solid line: <15 h/wk), (B) apparent free testosterone concentration (dotted line: ≥75 pmol/L, solid line: <75 pmol/L ), (C) parathyroid hormone concentration (dotted line: <45 pg/mL, solid line: ≥45 pg/mL), (D) diabetes (dotted line: nondiabetics, solid line: diabetics).

Predictive Parameters of Accelerated Muscle Loss in Men—MINOS Study

Background Aging-related muscle loss is a public health problem. We investigated the association of lifestyle and hormonal factors with a prospectively assessed muscle loss in older men. Methods Among 608 home-dwelling men, aged 60-85 (mean 68) years, lifestyle and health status were evaluated through a questionnaire. Appendicular skeletal muscle mass was estimated using dual-energy x-ray […]

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Reversible Nutritional Hypogonadism in a 22-Year-Old Man

Editor’s Note: There is such as thing as working out and dieting too much… A 22-year-old man presented with lack of libido and erectile dysfunction of 4 years duration for evaluation. Past medical history was remarkable for fat restriction with regular engagement in body-building exercises. Physical examination was normal without any signs of hypogonadism. Laboratory […]

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Testosterone Deficiency: A Comprehensive Review

Testosterone Deficiency is a highly prevalent and under-diagnosed condition associated both with aging and common medical comorbidities, including metabolic syndrome and cardiovascular disease. Early evidence suggests that testosterone replacement therapy may reverse early diabetes and improve overall male health. A comprehensive review of testosterone deficiency was published in the July issue of The American Journal […]

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