The American Journal of Medicine Blog

  Patients with nonvalvular atrial fibrillation commonly have comorbidities requiring concurrent use of oral anticoagulants and antiplatelets. There are no real-world data on the comparative safety of concomitant antithrombotic treatments in the era of direct oral anticoagulant (DOACs). Thus, we compared the incidence of intracranial hemorrhage, gastrointestinal bleeding, and other major bleeding between concomitant DOAC-antiplatelet […]

To the Editor: An 82-year-old woman presented to our outpatient clinic with a 6-month history of recurrent internal bleeding near the eyes. The patient had a history of type 2 diabetes mellitus, but had no significant medical history including traumatic injuries. Physical examination revealed bilateral periorbital ecchymosis and large tongue (Figure). Serum protein electrophoresis revealed […]

To the Editor: A 46-year-old man was seen by his hepatologist for a follow-up visit after successful treatment of hepatitis C. He reported a general weakness and walking pain for 10 days due to lower limb edema and knee arthralgia. His medical history included an intravenous heroin and cocaine addiction weaned off since 2001 and […]

We hypothesized that the clinical course of venous thromboembolism in patients with active cancer may differ according to the specificities of primary tumor site. Aim and Methods We used data from RIETE (international registry of patients with venous thromboembolism) to compare the clinical venous thromboembolism-related outcomes during the course of anticoagulation in patients with one […]

A 34-year-old woman presented with a 2-week history of intermittent painless macroscopic hematuria. She had a similar episode of macroscopic hematuria 5 years ago during her last pregnancy, which resolved spontaneously. Apart from this, she had no significant medical history. She was not taking any regular medications or supplements. On examination, she appeared well. She […]

Several studies have demonstrated an association between body mass index (BMI) and warfarin therapeutic dose, but none evaluated the association of BMI with the clinically important outcome of major bleeding in a community setting. To address this evidence gap, we conducted a case–control study to evaluate the association between BMI and major bleeding risk among […]