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Diffuse nonpainful ecchymoses on posterior thighs in dependent areas.

Scurvy, a Not-So-Ancient Disease

A 65-year-old man with a history of alcohol and tobacco use and few medical interactions presented with 1 week of progressive dyspnea. Examination revealed a cachectic man with large areas of nonpainful ecchymoses on the posterior thighs (Figure). Additional skin findings included spider angiomata on the face and chest, scattered bruising on upper extremities, and […]

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Red Wine Prevents the Acute Negative Vascular Effects of Smoking

Moderate consumption of red wine is associated with fewer cardiovascular events. We investigated whether red wine consumption counteracts the adverse vascular effects of cigarette smoking. Methods Participants smoked 3 cigarettes alone or after drinking a titrated volume of red wine. Clinical chemistry, blood counts, plasma cytokine enzyme-linked immunosorbent assays, immunomagnetic separation of CD14+monocytes for gene […]

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Moderate Alcohol Consumption Is Not Associated with Reduced All-cause Mortality

A large body of research suggests that light or moderate alcohol consumption is associated with reduced all-cause mortality. However, concerns remain that the observed relationship is due to selection bias, misclassification of ex-drinkers, or residual confounding. Methods The association between alcohol consumption and all-cause mortality was analyzed using Cox regression. The analysis was performed using […]

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Physical examination showed a pronounced asymmetry of the supraclavicular fossae.

Transient Unilateral Neck Swelling After Unusual Exertion

A 32-year-old right-handed female veterinarian presented with a spontaneous, painless swelling of the right supraclavicular fossa and lower neck. She denied fever, night sweats, or weight loss. Before this presentation she was in excellent health. The physical examination showed a pronounced asymmetry of the supraclavicular fossae ; the vital signs were normal, and there was no […]

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Alcohol and Illicit Drug Use as Precipitants of Atrial Fibrillation in Young Adults: A Case Series and Literature Review

Alcohol and illicit drugs are associated with atrial fibrillation. Avoidance of these substances can help prevent further paroxysms. Apart from avoidance, there are no existing guidelines on the management of lone atrial fibrillation, precipitated by alcohol/illicit drugs. “Real life” management varies widely. Abstract Background Atrial fibrillation in young patients (≤45 years) is uncommon. There is […]

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Secular Trends in Alcohol Consumption over 50 Years: The Framingham Study

Fifty years of self-reported alcohol consumption data was analyzed to determine patterns of alcohol use and disorders. Researchers found a decrease in average intake but an increase in wine consumption. The cumulative incidence of alcohol use disorders, however, did not decrease.AbstractBackgroundPopulation trends in patterns of alcohol use are important data for policymakers but are generally […]

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