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CancerBreast CancerMammography Screening Among the Elderly: A Research Challenge

Mammography Screening Among the Elderly: A Research Challenge

Black and white women aged 75 to 84 years who had an annual mammography had lower 10-year breast cancer mortality than corresponding women who had biennial or no/irregular mammography.

 

Background

Randomized trials demonstrate clear benefits of mammography screening in women through age 74 years. We explored age- and race-specific rates of mammography screening and breast cancer mortality among women aged 69 to 84 years.

Methods

We analyzed Medicare claims data for women residing within Surveillance, Epidemiology and End Results geographic areas from 1995 to 2009 from 64,384 non-Hispanic women (4886 black and 59,498 white) and ascertained all primary breast cancer cases diagnosed between ages 69 and 84 years. The exposure was annual or biennial screening mammography during the 4 years immediately preceding diagnosis. The outcome was breast cancer mortality during the 10 years immediately after diagnosis.

Results

After adjustment for stage at diagnosis, radiation therapy, chemotherapy, comorbid conditions, and contextual socioeconomic status, hazard ratios (and 95% confidence intervals) for breast cancer mortality relative to no/irregular mammography at 10 years for women aged 69 to 84 years at diagnosis were 0.31 (0.29-0.33) for annual mammography and 0.47 (0.44-0.51) for biennial mammography among whites and 0.36 (0.29-0.44) for annual mammography and 0.47 (0.37-0.58) for biennial mammography among blacks. Trends were similar at 5 years overall and stratified by ages 69 to 74 years, 75 to 78 years, and 79 to 84 years.

Conclusions

In these Medicare claims and Surveillance, Epidemiology and End Results data, elderly non-Hispanic women who self-selected for annual mammography had lower 10-year breast cancer mortality than corresponding women who self-selected for biennial or no/irregular mammography. These findings were similar among black and white women. The data highlight the evidentiary limitations of data used for current screening mammography recommendations.

To read this article in its entirety and to view additional images please visit our website.

-Maureen Sanderson, PhD, Robert S. Levine, MD, Mary K. Fadden, MPH, Barbara Kilbourne, PhD, Maria Pisu, PhD, Van Cain, MS, Baqar A. Husaini, PhD, Michael Langston, PhD, Lisa Gittner, PhD, Roger Zoorob, MD, MPH1, George S. Rust, MD, MPH, Charles H. Hennekens, MD, DrPH

This article originally appeared in the December 2015 issue of The American Journal of Medicine.

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