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CME: LDL Cholesterol Lowering: How & How Low?

The American Journal of Medicine website has posted a new continuing medical education module on lowering cholesterol. LDL Cholesterol Lowering: How and How Low? Program Overview The latest American College of Cardiology/American Heart Association lipid management guidelines make two general statements: 1) that elevated LDL cholesterol levels should be treated with the drug class proven […]

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Reduction in Percent LDL Cholesterol or Attained LDL-C Levels or Both?

The role of low-density lipoprotein cholesterol (LDL-C) in the pathophysiology of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease, has been well documented in several studies. The decrease in LDL-C levels leads to a significant reduction in the risk of atherosclerotic cardiovascular disease. Statins have become the first line […]

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Major cardiovascular events in the cohort with attained LDL-C >70 mg/dL as a function of percent LDL-C reduction. LDL = low-density lipoprotein.

2013 Cholesterol Guidelines Revisited: Percent LDL Cholesterol Reduction or Attained LDL Cholesterol Level or Both for Prognosis?

The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guideline on the treatment of blood cholesterol recommends moderate- to high-intensity statins for patients with atherosclerotic cardiovascular disease but departs from the traditional treat-to-target approach. Whether percent low-density lipoprotein cholesterol (LDL-C) reduction or attained LDL-C levels add incremental prognostic value to statin dose is not […]

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Age- and sex-adjusted rate of deaths due to heart disease in the United States (1900-2011). Data were obtained from several sources.

Trends in Coronary Atherosclerosis: A Tale of Two Population Subgroups

Coronary artery disease presents an increasing burden on our public health system. It is important to emphasize prevention, while at the same time addressing the appropriate treatment of existing disease. Background We previously investigated trends in subclinical coronary artery disease and associated risk factors among autopsied non-elderly adults who died from nonnatural causes. Although grade […]

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American Journal of Medicine Editor Joseph Alpert

A Few Unpleasant Facts

A Few Unpleasant Facts About Atherosclerotic Arterial Disease in the United States and the World Heart disease continues to be the number one cause of death for both men and women in the United States. The majority of these patients die as a result of atherosclerosis involving the heart and cardiovascular system. Atherosclerosis is a […]

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American Journal of Medicine Editor Joseph Alpert

Should Physicians Measure High-sensitivity C-reactive Protein Levels to Assess Coronary Heart Disease Risk?

When I was a medical student, atherosclerosis was seen as a process resembling the deposition of calcium deposits in pipes in an old house with gradual accumulation of precipitated minerals on the inner walls of these pipes. Basic science and clinical research over the last 40 years have made it clear that the process that […]

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