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Appropriate Use of Proton Pump Inhibitors: A Double-Edged Sword

We read with great interest the article published by Wombell et al in the current issue of The American Journal of Medicine. The authors summarize the evidence linking proton pump inhibitors (PPIs) to hospital-acquired Clostridium difficile infection.1 They also provide a description of the possible mechanisms responsible for this association. We commend the authors for their timely contribution to the […]

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Antimicrobial Use & C. difficile

Antimicrobial Use and Risk for Recurrent Clostridium difficile Infection Antimicrobial therapy after an episode of Clostridium difficile is common and significantly increases the risk of recurrent disease. The added risk associated with antimicrobial exposure (regardless of duration) should be considered if such therapy is contemplated. Abstract Background Although antimicrobial use during and immediately after Clostridium […]

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