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The association between body mass index and efficacy and safety endpoints. The solid lines represent the incidence ratio (per 100 person-years) at each body mass index interval. The dashed lines represent the upper and lower bounds of the 95% confidence interval. The bars represent the distribution of body mass index values. The P values are for unadjusted trends.

Body Mass Index, Intensive Blood Pressure Management, and Cardiovascular Events in the SPRINT Trial

It is unclear whether intensive blood pressure management is well-tolerated and affects risk uniformly across the body mass index (BMI) spectrum. Methods The randomized, controlled Systolic Blood Pressure Intervention Trial (SPRINT) included 9361 individuals ≥50 years of age at high cardiovascular risk, without diabetes mellitus, with systolic blood pressure between 130 and 180 mmHg. Participants […]

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Joseph S. Alpert

Diet Redux: Which Food Type Leads to Heart Attacks?

No topic has been more hotly debated over recent decades than the role of various foods in the development of atherosclerosis. The earliest animal experiments demonstrated that diets rich in fat and cholesterol produced arterial lesions that resembled atherosclerosis in humans.1 Over subsequent decades, a great deal of animal and human research has been performed exploring […]

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Diffuse nonpainful ecchymoses on posterior thighs in dependent areas.

Scurvy, a Not-So-Ancient Disease

A 65-year-old man with a history of alcohol and tobacco use and few medical interactions presented with 1 week of progressive dyspnea. Examination revealed a cachectic man with large areas of nonpainful ecchymoses on the posterior thighs (Figure). Additional skin findings included spider angiomata on the face and chest, scattered bruising on upper extremities, and […]

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vegetable juices and veggies on a table

How Pure is PURE? Dietary Lessons Learned and Not Learned From the PURE Trials

The Prospective Urban Rural Epidemiology (PURE) cohort studies add a new level of understanding of some key environmental components of health.1 The population is diverse, and represents individuals from various socioeconomic levels with a long period of follow-up. The dietary macronutrient analysis of this cohort conducted by the study group2 has yielded interesting findings, undoubtedly warranting additional […]

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Global mortality rates in males due to cardiovascular disease; originally published jointly by the World Health Organization in collaboration with the World Heart Federation and World Stroke Organization in 2011 as part of the Global Atlas On Cardiovascular Disease Prevention and Control; permission granted by World Heart Federation, November 14, 2017 and World Health Organization, November 23, 2017 (Permission access number 243602).

The Deficit of Nutrition Education of Physicians

Globally, death rates from cardiovascular disease are increasing, rising 41% between 1990 and 2013, and are often attributed, at least in part, to poor diet quality. With urbanization, economic development, and mass marketing, global dietary patterns have become more Westernized to include more sugar-sweetened beverages, highly processed foods, animal-based foods, and fewer fruits and vegetables, […]

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young female doctor standing by pile of produce

Dietary Patterns and Long-Term Survival (video)

Dietary patterns are related to mortality in selected populations with comorbidities. We studied whether dietary patterns are associated with long-term survival in a middle-aged, healthy population. Methods In this observational cohort study at the Cooper Clinic preventive medicine center (Dallas, Tex), a volunteer sample of 11,376 men and women with no history of myocardial infarction […]

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