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Young Adults and Adverse Childhood Events: A Potent Measure of Cardiovascular Risk

  While cardiovascular disease is the leading cause of death, its determinants include unhealthy behaviors and clinical risk factors and are recognized as the “actual causes” of death. Risk likely accumulates over the life course, and adverse childhood experiences may increase the risk of “actual causes” of death. The objectives of the study are to […]

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Magnitude of Venous Thromboembolism Risk in US Hospitals: Impact of Evolving National Guidelines for Prevention of Venous Thromboembolism

  The annual number of US hospital discharges at risk for venous thromboembolism and the impact of evolving American College of Chest Physicians (ACCP) consensus guidelines for prevention of venous thromboembolism are unknown. Methods Three risk-assessment algorithms based on 2004, 2008, and 2012 ACCP guidelines for prevention of venous thromboembolism were applied to the 2014 […]

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Marijuana’s Effects on Brain Structure and Function: What Do We Know and What Should We Do? A Brief Review and Commentary

The present epidemic of opioid addiction and the enthusiasm about marijuana use by advocates of its legalization may have diverted attention from its reported adverse health effects. These include clinical studies that demonstrate chronic marijuana use is associated with long-term deleterious effects on cognition.1 Neuroscientists have been carefully pairing neurodiagnostic tools with newer neuroimaging technologies to […]

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Risk Estimation in Type 2 Myocardial Infarction and Myocardial Injury: The TARRACO Risk Score

Despite adverse prognoses of type 2 myocardial infarction and myocardial injury, an effective, practical risk stratification method remains an unmet clinical need. We sought to develop an efficient clinical bedside tool for estimating the risk of major adverse cardiovascular events at 180 days for this patient population. METHODS The derivation cohort included patients with type […]

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The Call for a Physical Activity Vital Sign in Clinical Practice

According to the Bureau of Labor Statistics, the most common shared occupational health risk is sedentary behavior. Physical inactivity increases the relative risk of coronary artery disease, stroke, hypertension, and osteoporosis by 45%, 60%, 30%, and 59%, respectively. Epidemiologic data suggest that physical inactivity is associated with an increased risk of 25 chronic diseases. Because approximately 90% […]

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A Tool to Assess Risk of De Novo Opioid Abuse or Dependence

Readily available demographic, clinical, behavioral, pharmacy, and geographic information can be used to predict the likelihood of opioid abuse or dependence. Determining risk factors for opioid abuse or dependence will help clinicians practice informed prescribing and may help mitigate opioid abuse or dependence. The purpose of this study is to identify variables predicting opioid abuse […]

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