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Bone Density Testing Is the Best Way to Monitor Osteoporosis Treatment

Bone mineral density assessment by dual-energy X-ray absorptiometry is the most widely available and best validated clinical tool to diagnose osteoporosis, assess fracture risk, and monitor the skeletal effects of medications that reduce fracture risk.1 However, dual-energy X-ray absorptiometry testing remains underused with osteoporosis undertreated. This treatment gap has reached crisis proportions,2 with recent disturbing evidence that […]

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Osteoporosis in the Women’s Health Initiative: Another Treatment Gap?

Osteoporotic fractures are associated with high morbidity, mortality, and cost. Methods We performed a post hoc analysis of the Women’s Health Initiative (WHI) clinical trials data to assess osteoporosis treatment and identify participant characteristics associated with utilization of osteoporosis medication(s) after new diagnoses of osteoporosis or fracture. Information from visits prior to and immediately subsequent […]

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Osteoporosis

Western Osteoporosis Alliance Clinical Practice Series: Evaluating the Balance of Benefits and Risks of Long-Term

Osteoporosis is a chronic disease that requires life-long strategies to reduce fracture risk. Few trials have investigated the balance of benefits and risk with long-term use of osteoporosis therapies, and fewer still have investigated the consequences of treatment discontinuation. The best available evidence suggests that up to 10 years of treatment with an oral bisphosphonate […]

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Time to Clinically Relevant Fracture Risk Scores in Postmenopausal Women

Clinical practice guidelines recommend use of fracture risk scores for screening and pharmacologic treatment decisions. The timing of occurrence of treatment-level (according to 2014 National Osteoporosis Foundation guidelines) or screening-level (according to 2011 US Preventive Services Task Force guidelines) fracture risk scores has not been estimated in postmenopausal women. Methods We conducted a retrospective competing […]

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Trends in osteoporosis screening by age among women enrolled in commercial or Medicare Advantage plans, 2008-2014.

Trends and Disparities in Osteoporosis Screening Among Women in the United States, 2008-2014

The United States Preventive Services Task Force recommends universal osteoporosis screening among women ages 65+ and targeted screening of younger women, but historically, adherence to these evidence-based recommendations has been suboptimal. Methods To describe contemporary patterns of osteoporosis screening, we conducted a retrospective analysis using the OptumLabs™ Data Warehouse, a database of de-identified administrative claims, which […]

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Models of mediation and moderation analyses. Models of used for PROCESS to theoretically assess mediation and moderation of the effects of heavy cannabis use on bone mineral density outcomes.

Heavy Cannabis Use Is Associated With Low Bone Mineral Density and an Increased Risk of Fractures

To investigate possible associations between recreational cannabis use and bone health in humans. Methods Cross-sectional study of individuals recruited from primary care in the UK between 2011 and 2013. Cases were regular smokers of cannabis divided into moderate (n = 56) and heavy user (n = 144) subgroups depending on whether they reported fewer or more than […]

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