American Journal of Medicine, internal medicine, medicine, health, healthy lifestyles, cancer, heart disease, drugs

Provoked Dizziness from Bow Hunter’s Syndrome

  A 62-year-old man was experiencing debilitating bouts of dizziness provoked by head rotation until ultimately finding relief with cervical spine fixation. He had a history of coronary artery disease, human immunodeficiency virus, tobacco use disorder, and generalized anxiety, and initially presented to a routine primary care visit with 3 weeks of episodic dizziness. During […]

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detail of cancer cell

Hepatocellular Carcinoma Screening Associated with Early Tumor Detection and Improved Survival Among Patients with Cirrhosis in the US

Professional societies recommend hepatocellular carcinoma screening in patients with cirrhosis, but high-quality data evaluating its effectiveness to improve early tumor detection and survival in “real world” clinical practice are needed. We aim to characterize the association between hepatocellular carcinoma screening and early tumor detection, curative treatment, and overall survival among patients with cirrhosis. Methods We […]

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Single High-Sensitivity Cardiac Troponin I to Rule Out Acute Myocardial Infarction

This study examined the performance of single high-sensitivity cardiac troponin I (hs-cTnI) measurement strategies to rule out acute myocardial infarction. Methods This was a prospective, observational study of consecutive patients presenting to the emergency department (n = 1631) in whom cTnI measurements were obtained using an investigational hs-cTnI assay. The goals of the study were to […]

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The Clinical Relevance of Studies on Borrelia burgdorferi Persisters

In North America, Lyme disease is principally caused by Borrelia burgdorferi sensu stricto, hereafter referred to as “B. burgdorferi.” It is acquired by the bite of an infected Ixodes tick. The most common clinical manifestation is a skin lesion, referred to as “erythema migrans,” which is due to cutaneous infection with B. burgdorferi. Other objective manifestations may involve the nervous […]

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doctor putting on gloves

Digital Rectal Exam: Still Relevant After All These Years (video)

In the world of high-tech medicine, the digital rectal exam still has a place. In this current study, researchers showed that performing the digital rectal exam on patients with acute gastrointestinal bleeding provided valuable clinical information. American Journal of Medicine Editor-in-Chief Dr. Joseph S. Alpert explains the clinical implications of this research. (Get out your exam […]

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The Coronary (Cardiac) Care Unit at 50 Years: A Major Advance in the Practice of Hospital Medicine

This year, 2017, marks the 50th anniversary commemorating the publication of an article describing the results from the classic study by Killip and Kimball showing a reduction in mortality from acute myocardial infarction in patients sequestered in a specialized hospital unit1 at New York Hospital in New York City. Also described in the article was the […]

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The History of the Salt Wars

The “Salt–Blood Pressure Hypothesis” states that an increase in the intake of salt leads to an increased in blood pressure and subsequently increases the risk for cardiovascular events, which has been a point of contention for decades. This article covers the history and some of the key players pertaining to “The Salt Wars” during the […]

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Dr. Joseph S. Alpert

Stem Cell Therapy: The Phoenix in Clinical Medicine?

The Phoenix is a mythical bird with brightly colored plumage known in ancient Greek for the legend of its rebirth. After a long life, the Phoenix dies in a fire of its own making and then rises again reborn from the ashes. This myth parallels current feverish beliefs concerning the ability of stem cell therapy […]

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elder woman sick in bed with husband looking on

Death and Dignity: Exploring Physicians’ Responsibilities After a Patient’s Death

Literature focused on care at the end of life is flourishing. The scope of this work has been broad, including how to best communicate bad news1, 2 or discuss patient wishes at the end of life,3, 4 as well as detailing where patients are dying and how it impacts their care5 and the value of palliative and hospice care during […]

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Non-Classic Cystic Fibrosis: The Value in Family History

To the Editor: Since the advent of the Human Genome Project, opening doors to an era of genomic medicine, the family history has become a relevant and critical tool in individualized disease prevention. The family history has lasted through the years as a key component of history-taking in medical education. Yet it continues to be […]

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